RT Journal Article
T1 Visible-light-mediated regioselective synthesis of novel thiazolo[3,2-b][1,2,4]triazoles: advantageous synthetic application of aqueous conditions.
A1 Aggarwa, Ranjana
A1 Hooda, Mona
A1 Kumar, Prince
A1 Torralba Martínez, María Del Carmen
AB From a green chemistry perspective, sustainable irradiation as the power source and water as the solvent have certainly grabbed the attention of chemists in recent times because their use helps reduce the hazardous ecological footprints of organic synthesis. In the present work, we have established an efficient, straightforward and green protocol for the regioselective synthesis of novel functionalized thiazolo[3,2-b][1,2,4]triazoles. The visible-light-mediated catalyst-free reaction of diversely substituted α-bromodiketones, generated in situ by the reaction of NBS and 1,3-diketones, with 3-mercapto[1,2,4]triazoles under aqueous conditions afforded thiazolo[3,2-b][1,2,4]triazole derivatives in excellent yields. The structure of the regioisomer has been confirmed explicitly by heteronuclear 2D-NMR [(1H–13C) HMBC, (1H–13C) HMQC] spectroscopic and X-ray crystallographic studies. Radical initiating and trapping experiments supported the free radical mechanism for the cyclization.
PB Royal Society of Chemistry
YR 2021
FD 2021-12-14
LK https://hdl.handle.net/20.500.14352/115997
UL https://hdl.handle.net/20.500.14352/115997
LA eng
NO Org. Biomol. Chem., 2022,20, 584-595
NO Council of Scientific and Industrial Research (CSIR), New Delhi, India
DS Docta Complutense
RD 18 abr 2025