RT Journal Article
T1 Targeting the Gut Microbiota of Vertically HIV-Infected Children to Decrease Inflammation and Immunoactivation: A Pilot Clinical Trial
A1 Sainz, Talía
A1 Diaz, Laura
A1 Rojo, David
A1 Clemente, María Isabel
A1 Barbas, Coral
A1 Gosalbes, María José
A1 Jiménez Hernández, Nuria
A1 Escosa, Luis
A1 Guillen, Sara
A1 Ramos Amador, José Tomás
A1 Muñoz Fernández, María Ángeles
A1 Navarro Gómez, María Luisa
A1 Mellado, María José
A1 Serrano Villar, Sergio
AB Aims: Children with HIV exhibit chronic inflammation and immune dysfunction despite antiretroviral therapy (ART). Strategies targeting persistent inflammation are needed to improve health in people living with HIV. The gut microbiota likely interacts with the immune system, but the clinical implications of modulating the dysbiosis by nutritional supplementation are unclear.Methods: Pilot, double-blind, randomized placebo-controlled trial in which 24 HIV-infected on ART were randomized to supplementation with a daily mixture of symbiotics, omega-3/6 fatty acids and amino acids, or placebo four weeks, in combination with ART. We analyzed inflammatory markers and T-cell activation changes and their correlations with shifts in fecal microbiota.Results: Twenty-four HIV-infected children were recruited and randomized to receive a symbiotic nutritional supplement or placebo. Mean age was 12 ± 3.9 years, 62.5% were female. All were on ART and had HIV RNA < 50/mL. We did not detect changes in inflammatory (IL-6, IL-7, IP-10), microbial translocation (sCD14), mucosal integrity markers (IFABP, zonulin) or the kynurenine to tryptophan ratio, or changes in markers of the adaptive immune response in relation to the intervention. However, we found correlations between several key bacteria and the assessed inflammatory and immunological parameters, supporting a role of the microbiota in immune modulation in children with HIV.Conclusions: In this exploratory study, a four-week nutritional supplementation had no significant effects in terms of decreasing inflammation, microbial translocation, or T-cell activation in HIV-infected children. However, the correlations found support the interaction between gut microbiota and the immune system.
PB MPDI
SN 2072-6643
YR 2022
FD 2022-02-23
LK https://hdl.handle.net/20.500.14352/71731
UL https://hdl.handle.net/20.500.14352/71731
LA eng
NO Instituto de Salud Carlos III (ISCIII)/ FEDER
NO Instituto de Salud Carlos III
NO Spanish Society of Microbiology and Infectious Diseases (SEIMC)/Spanish Ministry of Science and Innovation/Instituto de Salud Carlos III/FEDER
DS Docta Complutense
RD 5 abr 2025