RT Journal Article
T1 Paraquat Treatment Compromises the Clearance of β-Amyloid and Tau Proteins and Induces Primary Hippocampal Neuronal Cell Death through HSP70, P20S, and TFEB Disruption
A1 Moyano-Cires Ivanoff, Paula Viviana
A1 García Sánchez, José Manuel
A1 García Lobo, Jimena
A1 Frejo Moya, María Teresa
A1 Naval López, María Victoria
A1 Pino Sans, Javier Del
A1 Sanjuna, Javier
AB The herbicide paraquat (PQ) induces hippocampal neuronal cell loss and cognitive dysfunction after one and repeated treatment. All the mechanisms involved in these effects are not well understood. Single and repeated PQ treatment increased Aβ and tau protein levels, through HSP70 and TFEB downregulation and proteasome 20S inhibition, producing cell death in primary hippocampal neurons associated with cognitive decline. Our results reveal the mechanisms through which PQ could induce the accumulation of abnormal proteins and neurodegeneration that could originate the cognitive decline produced by it and could help managing its degenerative effects.
PB ACS Publications
YR 2020
FD 2020
LK https://hdl.handle.net/20.500.14352/116568
UL https://hdl.handle.net/20.500.14352/116568
LA eng
NO Paula Moyano, Javier Sanjuna, José Manuel Garcia, Jimena Garcia, María Teresa Frejo, María Victoria Naval, and Javier del Pino Chemical Research in Toxicology 2021 34 (5), 1240-1244 DOI: 10.1021/acs.chemrestox.0c00370
NO Banco Santander
NO Universidad Complutense de Madrid
DS Docta Complutense
RD 15 abr 2025