RT Journal Article
T1 Neuroprotective and Anti-Inflammatory Effects of Linoleic Acid in Models of Parkinson’s Disease: The Implication of Lipid Droplets and Lipophagy
A1 Alarcón Gil, Jesús
A1 Sierra Magro, Ana
A1 Morales García, José Ángel
A1 Sanz SanCristóbal, Marina
A1 Alonso Gil, Sandra
A1 Cortes Canteli, Marta
A1 Niso Santano, Mireia
A1 Martínez Chacón, Guadalupe
A1 Fuentes, Jose M.
A1 Santos Montes, Gregorio Ángel
A1 Pérez Castillo, Ana
AB Parkinson’s disease (PD) is the second most prevalent neurodegenerative disease after Alzheimer’s disease. The principal pathological feature of PD is the progressive loss of dopaminergic neurons in the ventral midbrain. This pathology involves several cellular alterations: oxidative stress, mitochondrial dysfunction, loss of proteostasis, and autophagy impairment. Moreover, in recent years, lipid metabolism alterations have become relevant in PD pathogeny. The modification of lipid metabolism has become a possible way to treat the disease. Because of this, we analyzed the effect and possible mechanism of action of linoleic acid (LA) on an SH-SY5Y PD cell line model and a PD mouse model, both induced by 6-hydroxydopamine (6-OHDA) treatment. The results show that LA acts as a potent neuroprotective and anti-inflammatory agent in these PD models. We also observed that LA stimulates the biogenesis of lipid droplets and improves the autophagy/lipophagy flux, which resulted in an antioxidant effect in the in vitro PD model. In summary, we confirmed the neuroprotective effect of LA in vitro and in vivo against PD. We also obtained some clues about the novel neuroprotective mechanism of LA against PD through the regulation of lipid droplet dynamics.
PB MDPI
SN 2073-4409
YR 2022
FD 2022-07-26
LK https://hdl.handle.net/20.500.14352/111048
UL https://hdl.handle.net/20.500.14352/111048
LA eng
NO Alarcon-Gil, J.; Sierra-Magro, A.; Morales-Garcia, J.A.; Sanz-SanCristobal, M.; Alonso-Gil, S.; Cortes-Canteli, M.; Niso-Santano, M.; Martínez-Chacón, G.; Fuentes, J.M.; Santos, A.; et al. Neuroprotective and Anti-Inflammatory Effects of Linoleic Acid in Models of Parkinson’s Disease: The Implication of Lipid Droplets and Lipophagy. Cells 2022, 11, 2297. https://doi.org/10.3390/cells11152297
NO Instituto de Salud Carlos III
NO Ministerio de Economía y Competitividad (España)
NO Comunidad Autónoma de Madrid
NO Unión Europea
DS Docta Complutense
RD 12 may 2026