RT Journal Article
T1 Microvesicles: ROS scavengers and ROS producers
A1 Bodega, G.
A1 Alique, Matilde
A1 Puebla, L.
A1 Carracedo Añón, Julia María
A1 Ramírez, R. M.
AB This review analyzes the relationship between microvesicles and reactive oxygen species (ROS). This relationship is bidirectional; on the one hand, the number and content of microvesicles produced by the cells are affected by oxidative stress conditions; on the other hand, microvesicles can directly and/or indirectly modify the ROS content in the extra- as well as the intracellular compartments. In this regard, microvesicles contain a pro-oxidant or antioxidant machinery that may produce or scavenge ROS: direct effect. This mechanism is especially suitable for eliminating ROS in the extracellular compartment. Endothelial microvesicles, in particular, contain a specific and well-developed antioxidant machinery. On the other hand, the molecules included in microvesicles can modify (activate or inhibit) ROS metabolism in their target cells: indirect effect. This can be achieved by the incorporation into the cells of ROS metabolic enzymes included in the microvesicles, or by the regulation of signaling pathways involved in ROS metabolism. Proteins, as well as miRNAs, are involved in this last effect.
PB Taylor & Francis
SN 2001-3078
YR 2019
FD 2019-06-17
LK https://hdl.handle.net/20.500.14352/13838
UL https://hdl.handle.net/20.500.14352/13838
LA eng
NO Instituto de Salud Carlos III/FEDER
NO Universidad Complutense de Madrid
NO Universidad de Alcalá de Henares
NO Sociedad Española de Nefrologia
DS Docta Complutense
RD 12 abr 2025