%0 Journal Article
%A Santos-Lozano, Alejandro
%A Valenzuela, Pedro L.
%A Llavero, Francisco
%A Lista, Simone
%A Carrera-Bastos, Pedro
%A Hampel, Harald
%A Pareja-Galeano, Helios
%A González Gálvez, Beatriz
%A López, Juan Antonio
%A Vázquez, Jesús
%A Emanuele, Enzo
%A Zugaza, José L.
%A Lucia, Alejandro
%T Successful aging: insights from proteome analyses of healthy centenarians
%D 2020
%@ 1945-4589
%U https://hdl.handle.net/20.500.14352/104842
%X Healthy aging depends on a complex gene-environment network that is ultimately reflected in the expression of different proteins. We aimed to perform a comparative analysis of the plasma proteome of healthy centenarians (n=9, 5 women, age range 100-103 years) with a notably preserved ambulatory capacity (as a paradigm of 'successful' aging), and control individuals who died from a major age-related disease before the expected life expectancy (n=9, 5 women, age range: 67-81 years), and while having impaired ambulatory capacity (as a paradigm of 'unsuccessful' aging). We found that the expression of 49 proteins and 86 pathways differed between the two groups. Overall, healthy centenarians presented with distinct expression of proteins/pathways that reflect a healthy immune function, including a lower pro-inflammatory status (less 'inflammaging' and autoimmunity) and a preserved humoral immune response (increased B cell-mediated immune response). Compared with controls, healthy centenarians also presented with a higher expression of proteins involved in angiogenesis and related to enhanced intercellular junctions, as well as a lower expression of proteins involved in cardiovascular abnormalities. The identification of these proteins/pathways might provide new insights into the biological mechanisms underlying the paradigm of healthy aging.
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