RT Journal Article
T1 Successful aging: insights from proteome analyses of healthy centenarians
A1 Santos-Lozano, Alejandro
A1 Valenzuela, Pedro L.
A1 Llavero, Francisco
A1 Lista, Simone
A1 Carrera-Bastos, Pedro
A1 Hampel, Harald
A1 Pareja-Galeano, Helios
A1 González Gálvez, Beatriz
A1 López, Juan Antonio
A1 Vázquez, Jesús
A1 Emanuele, Enzo
A1 Zugaza, José L.
A1 Lucia, Alejandro
AB Healthy aging depends on a complex gene-environment network that is ultimately reflected in the expression of different proteins. We aimed to perform a comparative analysis of the plasma proteome of healthy centenarians (n=9, 5 women, age range 100-103 years) with a notably preserved ambulatory capacity (as a paradigm of 'successful' aging), and control individuals who died from a major age-related disease before the expected life expectancy (n=9, 5 women, age range: 67-81 years), and while having impaired ambulatory capacity (as a paradigm of 'unsuccessful' aging). We found that the expression of 49 proteins and 86 pathways differed between the two groups. Overall, healthy centenarians presented with distinct expression of proteins/pathways that reflect a healthy immune function, including a lower pro-inflammatory status (less 'inflammaging' and autoimmunity) and a preserved humoral immune response (increased B cell-mediated immune response). Compared with controls, healthy centenarians also presented with a higher expression of proteins involved in angiogenesis and related to enhanced intercellular junctions, as well as a lower expression of proteins involved in cardiovascular abnormalities. The identification of these proteins/pathways might provide new insights into the biological mechanisms underlying the paradigm of healthy aging.
SN 1945-4589
YR 2020
FD 2020-02-25
LK https://hdl.handle.net/20.500.14352/104842
UL https://hdl.handle.net/20.500.14352/104842
LA eng
NO Universidad Europea de Madrid (#2017/UEM05).
NO Universidad de Alcalá de Henares
NO Ministerio de Ciencia, Innovación y Universidades
NO Fundació Marató TV3
NO Fundacion "La Caixa"
DS Docta Complutense
RD 25 abr 2025