RT Journal Article
T1 Burden of Respiratory Syncytial Virus Infection in Children and Older Patients Hospitalized with Asthma: A Seven-Year Longitudinal Population-Based Study in Spain
A1 Gómez García, Rosa
A1 Jiménez García, Rodrigo
A1 López De Andrés, Ana Isabel
A1 Hernández Barrera, Valentín
A1 Carabantes Alarcón, David
A1 Zamorano León, José Javier
A1 Cuadrado Corrales, María Natividad
A1 Jiménez Sierra, Ana
A1 Miguel Díez, Javier De
AB (1) Background: To describe hospitalizations due to respiratory syncytial virus (RSV) infection among children and elderly patients with asthma. (2) Methods: We used a nationwide discharge database to select patients with asthma aged 0 to 15 years and >= 65 years admitted to Spanish hospitals from 2016 to 2022. (3) Results: We identified 49,086 children and 471,947 elderly patients hospitalized with asthma (3.52% and 0.51%, respectively, with RSV). The proportion of RSV increased over time in children with asthma (from 1.44% to 7.4%, p < 0.001) and in elderly individuals (from 0.17% to 1.01%, p < 0.001). Among children with RSV infection, the presence of influenza (OR 3.65; 95% CI 1.46-9.1) and pneumonia (OR 1.85; 95% CI 1.02-3.55) increased the risk of poor outcome. The presence of RSV was associated with severity in these patients, defined by use of mechanical ventilation and/or admission to the intensive care unit (OR 1.44; 95% CI 1.11-1.86). In elderly patients with RSV infection, older age, congestive heart failure, COVID-19, and pneumonia increased the risk of in-hospital mortality (IHM). However, RSV infection was not associated with IHM (OR 0.88; 95% CI 0.68-1.15) in these patients. (4) Conclusion: Our results highlight the impact of RSV infection in children and elderly patients hospitalized with asthma. Strategies to improve surveillance, prophylaxis, and management of RSV infection should be evaluated.
PB MDPI
YR 2024
FD 2024-09-18
LK https://hdl.handle.net/20.500.14352/117900
UL https://hdl.handle.net/20.500.14352/117900
LA eng
NO Rosa María Gomez-Garcia , Rodrigo Jiménez-Garcia , Ana López-de-Andrés , Valentín Hernández-Barrera  , David Carabantes-Alarcon , José J. Zamorano-León , Natividad Cuadrado-Corrales, Ana Jiménez-Sierra and Javier De-Miguel-Diez
NO Comunidad Autónoma de Madrid
NO Universidad Complutense de Madrid
DS Docta Complutense
RD 16 abr 2025