RT Journal Article
T1 Pathological effects of pulmonary vein beta-radiation in a swine model
A1 Pérez Castellano, Nicasio
A1 Pérez Villacastín Domínguez, Julián
A1 Aragoncillo Ballesteros, Paloma
A1 Fantidis, Panayotis
A1 Sabaté, Manel
A1 García Torrent, María Jesús
A1 Prieto Martín, Carlos
A1 Corral, José M.
A1 Moreno, Javier
A1 Fernández Ortiz, Antonio Ignacio
A1 Vaño Carruana, Eliseo
A1 Macaya Miguel, Carlos
AB Introduction: Atrial fibrillation (AF) may be triggered by ectopic beats originating in sleeves of atrial myocardium entering the pulmonary veins (PVs). PV isolation by means of circumferential ostial or atrial radiofrequency ablation is an effective but also a difficult and long procedure, requiring extensive applications that can have serious potential complications. Our objective was to examine pathological effects of PV β-radiation, particularly the ability to destroy PV myocardial sleeves without inducing PV stenosis and other unwanted effects, in order to establish its potential feasibility for the treatment of AF.Methods and Results: Ten minipigs were studied. A phosphorus-32 source wire centered within a 2.5-mm diameter balloon catheter (Galileo® III Intravascular Radiotherapy System, Guidant, Santa Clara, CA, USA) was used to deliver β-radiation to the superior wall of the right PV trunk. Pathological analysis was performed either immediately after ablation (2 pigs) or 81 ± 27 days later (8 pigs). Acute effects of PV β-radiation consisted of endothelial denudation covered by white thrombus, elastic lamina disruption, and PV sleeve necrosis. Late effects consisted of mild focal neointimal hyperplasia that reduced the PV luminal area by only 1.3 ± 1.8%, elastic lamina thickening, and PV sleeve fibrosis. Four of these 8 PVs were completely re-endothelized. Lesions were transmural in 6 of 10 radiated PVs and segmental, involving 28 ± 7% of the right PV perimeter.Conclusion: Intravascular β-radiation can induce transmural necrosis and fibrosis of PV myocardial sleeves without PV stenosis and other unwanted effects, which supports a potential usefulness of this energy source in the treatment of AF.
PB Wiley
SN 1045-3873
YR 2006
FD 2006-06-01
LK https://hdl.handle.net/20.500.14352/98788
UL https://hdl.handle.net/20.500.14352/98788
LA eng
NO Pérez-Castellano N, Villacastín J, Aragoncillo P, Fantidis P, Sabaté M, García-Torrent MJ, Prieto C, Corral JM, Moreno J, Fernández-Ortiz A, Vano E, Macaya C. Pathological effects of pulmonary vein beta-radiation in a swine model. J Cardiovasc Electrophysiol. 2006 Jun;17(6):662-9. doi: 10.1111/j.1540-8167.2006.00462.x. PMID: 16836719.
NO Sociedad Española de Cardiología
DS Docta Complutense
RD 8 abr 2025