RT Conference Proceedings
T1 Pharmacokinetics of marbofloxacin, after single intravenous administrations, in buffaloes calves
A1 Baroni, Eduardo
A1 Rodríguez Fernández, Casilda
A1 Crudeli, G.
A1 Perone, C
A1 Lucas Burneo, José Julio De
A1 San Andrés Larrea, Manuel Ignacio
A1 Rubio Langre, Sonia
AB Marbofloxacin is a synthetic, bactericidal antimicrobial, belonging to the fluoroquinolone group which acts by inhibition of DNA gyrase and those acts by concentration dependant killing mechanism, so high plasma concentration initially is important. This drug is a fluoroquinolone developed exclusively for veterinary use, and exhibit high bactericidal activity against a broad spectrum of aerobic gram-negative, some gram-positive bacteria and Mycoplasma spp. The pharmacokinetic behaviour of marbofloxacin was investigated after intravenous (2 mg/kg) in five clinically healthy buffaloes (10 days-old). Plasma concentrations of the marbofloxacin were determined by a HPLC/u.v. method. After intravenous administration, marbofloxacin in buffaloes was characterized by a AUC = 8,42±3,71 μg·h/ml, a large volume of distribution (Vss=1.59±0.55 L/kg) and a long persistence with an elimination half-life (t½λ) of 4.6±0,31 h, and MRT 5,90±0,57h. Furthermore, marbofloxacin in buffaloes was characterized by a relatively low total body clearance (Cl) of 0.28±0.12 L/kg·h.
SN 1594-4077
YR 2007
FD 2007
LK https://hdl.handle.net/20.500.14352/112341
UL https://hdl.handle.net/20.500.14352/112341
LA eng
NO Baroni, E. E., Rodríguez, C., Crudeli, G., Perone, C., Rubio, S., de Lucas, J. J., & San Andrés, M. I. (2007). Pharmacokinetics of marbofloxacin, after single intravenous administrations, in buffaloes calves. Italian Journal of Animal Science, 6(sup2), 838–841. https://doi.org/10.4081/ijas.2007.s2.838
DS Docta Complutense
RD 5 abr 2025