RT Journal Article
T1 Borrelia burgdorferi infection induces long-term memory-like responses in macrophages with tissue-wide consequences in the heart
A1 Barriales, Diego
A1 Martín-Ruiz, Itziar
A1 Carreras-González, Ana
A1 Montesinos-Robledo, Marta
A1 Azkargorta, Mikel
A1 Iloro, Ibon
A1 Escobés, Iraide
A1 Martín-Mateos, Teresa
A1 Atondo, Estibaliz
A1 Palacios, Ainhoa
A1 Gonzalez-Lopez, Monika
A1 Bárcena, Laura
A1 Cortázar, Ana R.
A1 Cabrera, Diana
A1 Peña-Cearra, Ainize
A1 van Liempd, Sebastiaan M.
A1 Falcón-Pérez, Juan M.
A1 Pascual-Itoiz, Miguel A.
A1 Flores Landeira, Juana María
A1 Abecia, Leticia
A1 Pellon, Aize
A1 Martínez-Chantar, Maria Luz
A1 Aransay, Ana M.
A1 Pascual, Alberto
A1 Elortza, Felix
A1 Berra, Edurne
A1 Lavín, José Luis
A1 Rodríguez, Héctor
A1 Anguita, Juan
AB Lyme carditis is an extracutaneous manifestation of Lyme disease characterized by episodes of atrioventricular block of varying degrees and additional, less reported cardiomyopathies. The molecular changes associated with the response to Borrelia burgdorferi over the course of infection are poorly understood. Here, we identify broad transcriptomic and proteomic changes in the heart during infection that reveal a profound down-regulation of mitochondrial components. We also describe the long-term functional modulation of macrophages exposed to live bacteria, characterized by an augmented glycolytic output, increased spirochetal binding and internalization, and reduced inflammatory responses. In vitro, glycolysis inhibition reduces the production of tumor necrosis factor (TNF) by memory macrophages, whereas in vivo, it produces the reversion of the memory phenotype, the recovery of tissue mitochondrial components, and decreased inflammation and spirochetal burdens. These results show that B. burgdorferi induces long-term, memory-like responses in macrophages with tissue-wide consequences that are amenable to be manipulated in vivo
PB Public Library of Science
SN 1545-7885
YR 2021
FD 2021-01-04
LK https://hdl.handle.net/20.500.14352/125908
UL https://hdl.handle.net/20.500.14352/125908
LA eng
NO Barriales, D., Martín-Ruiz, I., Carreras-González, A., Montesinos-Robledo, M., Azkargorta, M., Iloro, I., Escobés, I., Martín-Mateos, T., Atondo, E., Palacios, A., Gonzalez-Lopez, M., Bárcena, L., Cortázar, A. R., Cabrera, D., Peña-Cearra, A., van Liempd, S. M., Falcón-Pérez, J. M., Pascual-Itoiz, M. A., Flores, J. M., Abecia, L., … Anguita, J. (2021). Borrelia burgdorferi infection induces long-term memory-like responses in macrophages with tissue-wide consequences in the heart. PLoS biology, 19(1), e3001062. https://doi.org/10.1371/journal.pbio.3001062
NO Author Contributions Conceptualization: Juan Anguita. Formal analysis: Mikel Azkargorta, Ana R. Corta´zar, Juan M. Falcón-Pérez, Ana M. Aransay, Felix Elortza, Jose´ Luis Lavı´n, Juan Anguita. Funding acquisition: Leticia Abecia, Maria Luz Martı´nez-Chantar, Alberto Pascual, Edurne Berra, Héctor Rodríguez, Juan Anguita. Investigation: Diego Barriales, Itziar Martín-Ruiz, Ana Carreras-González, Marta Montesinos-Robledo, Ibon Iloro, Iraide Escobes, Teresa Martı´n-Mateos, Estibaliz Atondo, Ainhoa Palacios, Monika Gonzalez-Lopez, Laura Ba´rcena, Diana Cabrera, Ainize Peña-Cearra, Sebastiaan M. van Liempd, Miguel A. Pascual-Itoiz, Juana Marı´a Flores, Aize Pellon. Supervision: Juan Anguita. Visualization: Diego Barriales, Juan Anguita. Writing – original draft: Diego Barriales, Juan Anguita. Writing – review & editing: Itziar Martín-Ruiz, Ana Carreras-González, Marta Montesinos Robledo, Mikel Azkargorta, Ibon Iloro, Iraide Escobes, Teresa Martín-Mateos, Estibaliz Atondo, Monika Gonzalez-Lopez, Laura Bárcena, Ana R. Cortázar, Diana Cabrera, Ainize Peña-Cearra, Sebastiaan M. van Liempd, Juan M. Falco´n-Pe´rez, Miguel A. Pascual-Itoiz, Leticia Abecia, Aize Pellon, Maria Luz Martínez-Chantar, Ana M. Aransay, Alberto Pascual, Felix Elortza, Edurne Berra, José´ Luis Lavín, Héctor Rodríguez.
NO Ministerio de Ciencia, Innovación y Universidades ( España )
NO European Commission
NO Instituto de Salud Carlos III
NO la Fundación Vasca para la Innovación y la Investigación en Salud
NO Departamento de Salud · Gobierno Vasco
NO Junta de Andalucia
NO Fundación Domingo Martínez
DS Docta Complutense
RD 31 dic 2025