%0 Journal Article
%A Escribano Subías, María Pilar
%A Mesquida, Aina
%A López Montesinos, Sara
%A Reigadas, Elena
%A Muñoz, Patricia
%A Guinea, Jesús
%A Muñoz García, Patricia Carmen
%A Reigadas Ramírez, Elena Manuela
%T Amphotericin B, itraconazole, posaconazole, and isavuconazole MICs against clinical Mucorales isolates obtained by visual inspection and spectrophotometric reading according to the EUCAST 9.4 procedure
%D 2023
%@ 1369-3786
%@ 1460-2709
%U https://hdl.handle.net/20.500.14352/119230
%X We compared the antifungal susceptibility of 92 Mucorales isolates obtained by visual inspection and spectrophotometric readings following EUCAST (European Committee on Antimicrobial Susceptibility Testing) testing. Amphotericin B minimum inhibitory concentrations (MICs) were up to 1 mg/l against most isolates and variable among species, except for Cunninghamella bertholletiae. Posaconazole MICs against most isolates were up to 1 mg/l and high against Mucor circinelloides, some Rhizopus arrhizus, and Rhizopus microsporus. Isavuconazole MICs ranged between 1 and 8 mg/l but were invariably >8 mg/l against M. circinelloides and C. bertholletiae. The agreement between MICs obtained by visual endpoint or spectrophotometric readings was moderate and higher when using the ≥90% fungal growth inhibition endpoint.
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