RT Journal Article
T1 Amphotericin B, itraconazole, posaconazole, and isavuconazole MICs against clinical Mucorales isolates obtained by visual inspection and spectrophotometric reading according to the EUCAST 9.4 procedure
A1 Escribano Subías, María Pilar
A1 Mesquida, Aina
A1 López Montesinos, Sara
A1 Reigadas, Elena
A1 Muñoz, Patricia
A1 Guinea, Jesús
A1 Muñoz García, Patricia Carmen
A1 Reigadas Ramírez, Elena Manuela
AB We compared the antifungal susceptibility of 92 Mucorales isolates obtained by visual inspection and spectrophotometric readings following EUCAST (European Committee on Antimicrobial Susceptibility Testing) testing. Amphotericin B minimum inhibitory concentrations (MICs) were up to 1 mg/l against most isolates and variable among species, except for Cunninghamella bertholletiae. Posaconazole MICs against most isolates were up to 1 mg/l and high against Mucor circinelloides, some Rhizopus arrhizus, and Rhizopus microsporus. Isavuconazole MICs ranged between 1 and 8 mg/l but were invariably >8 mg/l against M. circinelloides and C. bertholletiae. The agreement between MICs obtained by visual endpoint or spectrophotometric readings was moderate and higher when using the ≥90% fungal growth inhibition endpoint.
PB Oxford University Press
SN 1369-3786
SN 1460-2709
YR 2023
FD 2023
LK https://hdl.handle.net/20.500.14352/119230
UL https://hdl.handle.net/20.500.14352/119230
LA eng
NO Pilar Escribano, Aina Mesquida, Sara López-Montesinos, Elena Reigadas, Patricia Muñoz, Jesús Guinea, Amphotericin B, itraconazole, posaconazole, and isavuconazole MICs against clinical Mucorales isolates obtained by visual inspection and spectrophotometric reading according to the EUCAST 9.4 procedure, Medical Mycology, Volume 61, Issue 5, May 2023, myad045, https://doi.org/10.1093/mmy/myad045
NO Fondo de Investigación SanitariaPlan Nacional de I+D+I 2017-2020European Regional Development Fund (FEDER) ‘A way of making Europe’
NO Instituto de Salud Carlos III
NO Unión Europea
DS Docta Complutense
RD 30 ago 2025