RT Journal Article
T1 NMDA receptor-BK channel coupling regulates synaptic plasticity in the barrel cortex
A1 Gómez García, Ricardo
A1 Maglio, Laura Eva
A1 González Hernández, Alberto Jesús
A1 Rivero Pérez, Belinda
A1 Bartolomé Martín, David
A1 Giráldez Fernández, Teresa
AB Postsynaptic N-methyl-D-aspartate receptors (NMDARs) are crucial mediators of synaptic plasticity due to their ability to act as coincidence detectors of presynaptic and postsynaptic neuronal activity. However, NMDARs exist within the molecular context of a variety of postsynaptic signaling proteins, which can fine-tune their function. Here, we describe a form of NMDAR suppression by large-conductance Ca2+- and voltage-gated K+ (BK) channels in the basal dendrites of a subset of barrel cortex layer 5 pyramidal neurons. We show that NMDAR activation increases intracellular Ca2+ in the vicinity of BK channels, thus activating K+ efflux and strong negative feedback inhibition. We further show that neurons exhibiting such NMDAR-BK coupling serve as high-pass filters for incoming synaptic inputs, precluding the induction of spike timing-dependent plasticity. Together, these data suggest that NMDAR-localized BK channels regulate synaptic integration and provide input-specific synaptic diversity to a thalamocortical circuit.
PB National Academy of Sciences
SN 0027-8424
YR 2021
FD 2021-08-31
LK https://hdl.handle.net/20.500.14352/92218
UL https://hdl.handle.net/20.500.14352/92218
LA eng
NO Gómez R, Maglio LE, Gonzalez-Hernandez AJ, Rivero-Pérez B, Bartolomé-Martín D, Giraldez T. NMDA receptor-BK channel coupling regulates synaptic plasticity in the barrel cortex. Proc Natl Acad Sci U S A. 2021 Aug 31;118(35):e2107026118. doi: 10.1073/pnas.2107026118.
NO Unión Europea
NO Ministerio de Ciencia, Innovación y Universidades
NO Ministerio de Educación, Cultura y Deporte
NO Cabildo Insular de Tenerife
DS Docta Complutense
RD 25 dic 2025