RT Journal Article
T1 The MAPK1/3 pathway is essential for the deregulation of autophagy observed in G2019S LRRK2 mutant fibroblasts
A1 Bravo San Pedro, José Manuel
A1 Gómez-Sánchez, Rubén
A1 Niso-Santano, Mireia
A1 Pizarro-Estrella, Elisa
A1 Aiastui-Pujana, Ana
A1 Gorostidi, Ana
A1 Climent, Vicente
A1 López de Maturana, Rakel
A1 Sanchez-Pernaute, Rosario
A1 López de Munain, Adolfo
A1 Fuentes, José M.
A1 González Polo, Rosa A.
AB The link between the deregulation of autophagy and cell death processes can be essential in the development of several neurodegenerative diseases, such as Parkinson disease (PD). However, the molecular mechanism of deregulation of this degradative process in PD patients is unknown. The leucine-rich repeat kinase 2 (LRRK2) gene is related to PD and its implication in autophagy regulation has been described. Our recent work shows that the presence of the G2019S LRRK2 mutation, one of the most prevalent in LRRK2, is accompanied by a deregulation of autophagy basal levels dependent on the MAPK1/3 (ERK2/1) pathway.
PB Taylor & Francis
YR 2012
FD 2012-10
LK https://hdl.handle.net/20.500.14352/128894
UL https://hdl.handle.net/20.500.14352/128894
LA eng
NO Bravo-San Pedro JM, Gómez-Sánchez R, Niso-Santano M, Pizarro-Estrella E, Aiastui-Pujana A, Gorostidi A, Climent V, López de Maturana R, Sanchez-Pernaute R, López de Munain A, Fuentes JM, González-Polo RA. The MAPK1/3 pathway is essential for the deregulation of autophagy observed in G2019S LRRK2 mutant fibroblasts. Autophagy. 2012 Oct;8(10):1537-1539. doi:10.4161/auto.21270.
NO Ministerio de Economía y Competitividad (Spain)
NO Instituto de Salud Carlos III (ISCIII)
NO CIBERNED (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas)
NO Junta de Extremadura
NO FUNDESALUD
DS Docta Complutense
RD 25 feb 2026