RT Journal Article
T1 Biocompatibility and Effectiveness of a Novel, Organic Olive Oil-Based Denture Adhesive: A Multicenter Randomized and Placebo-Controlled Clinical Trial
A1 Azevedo, Luís
A1 Correia, André
A1 Almeida, Carlos F.
A1 Molinero Mourelle, Pedro
A1 Correia, Maria
A1 Río Highsmith, Jaime Del
AB To assess the clinical efficacy of a novel, organic olive oil-based denture adhesive and its effect on Candida albicans growth in maxillary edentulous individuals wearing complete dentures, individuals were selected from two dental schools in Portugal and Spain. Twenty-eight complete dentures were relined, following a standardized protocol. The novel product (test) was compared with a commercialized adhesive (control) and Vaseline (placebo) randomly assigned in a cross-study design. The retention resistance was measured with a gnathometer and a dynamometer. The patients related outcome evaluations with a five-point questionnaire, and the Candida albicans growth in a Sabouraud dextrose agar (SDA) medium was used to evaluate differences between the placebo and experimental product. Twenty-three participants were included. The dynamometer evaluation showed significant differences between not using a denture adhesive and using either (experimental, p = 0.03; control, p = 0.04) and no significant differences between the two adhesives (p > 0.05). In the subjective analysis, the experimental adhesive showed a significantly longer effectiveness (p = 0.001), and the control reported better results in taste (p = 0.03) and in chewing (p = 0.001). The test adhesive showed better (p < 0.001) Candida albicans growth inhibition. The experimental adhesive showed longer effectiveness than the control and the placebo with a better inhibition capacity for the growth of Candida albicans. Patients reported better abilities for speech, chewing, taste, and retirement in the control adhesive.
PB MDPI
SN 1660-4601
YR 2021
FD 2021
LK https://hdl.handle.net/20.500.14352/87269
UL https://hdl.handle.net/20.500.14352/87269
LA eng
NO Azevedo, L.; Correia, A.; Almeida, C.F.; Molinero-Mourelle, P.; Correia, M.; Del Río Highsmith, J. Biocompatibility and Effectiveness of a Novel, Organic Olive Oil-Based Denture Adhesive: A Multicenter Randomized and Placebo-Controlled Clinical Trial. Int. J. Environ. Res. Public Health 2021, 18, 3398. https://doi.org/10.3390/ijerph18073398
DS Docta Complutense
RD 10 abr 2025