RT Journal Article
T1 Morphogenesis of the manubrium of sternum in human embryos: a new concept
A1 Rodríguez Vázquez, José Francisco
A1 Verdugo López, Samuel
A1 Garrido, José Manuel
A1 Murakami, Gen
A1 Kim, Ji Hyun
AB To revisit many theories on fetal development of the manubrium of the sternum, we examined 25 mid-term fetuses at 6-9 weeks of gestation. The initial developmental stage of the manubrium was characterized by a distinct interclavicular mesenchyme that was continuous with the developing clavicles. Because parts of the clavicle in which endochondral ossification occurs originate from the neural crest, the interclavicular mesenchyme seems to be of the same origin. The sternal bands, possibly of the lateral plate origin, were restricted at the anterior ends of the ribs in the paired thoracic walls. The interclavicular mesenchyme extended caudally and laterally to reach the anterior ends of the first ribs, and thus the interclavicular mesenchyme expanded into the intercostoclavicular mesenchyme. Then, the primitive manubrium was delimited by the sternoclavicular joint and its related ligaments, all of which developed from the interclavicular and intercostoclavicular mesenchymes. Although the first ribs were attached to the intercostoclavicular mesenchyme, the former was vimentin-negative in contrast to the latter, positive mesenchyme. Soon afterwards, the small upper end of the sternal bands was integrated into the intercostoclavicular mesenchyme to form the primitive manubrium. The infrahyoid muscles and their supplying nerves maintained a close topographical relation to the interclavicular or intercostoclavicular mesenchyme, whereas the pectoralis major muscle kept attachments to the sternal bands. Consequently, the manubrium of sternum appeared to develop in a complex way at a junction area between derivatives of the neural crest, lateral plate, and somite.
PB Wiley
SN 1932-8486
YR 2013
FD 2013-02
LK https://hdl.handle.net/20.500.14352/95852
UL https://hdl.handle.net/20.500.14352/95852
LA eng
NO Rodríguez-Vázquez JF, Verdugo-López S, Garrido JM, Murakami G, Kim JH. Morphogenesis of the manubrium of sternum in human embryos: a new concept. Anatomical Record (Hoboken). 2013 Feb;296(2):279-89.
DS Docta Complutense
RD 18 abr 2025