RT Journal Article
T1 Cutting Edge: Regulation of Exosome Secretion by the Integral MAL Protein in T Cells
A1 Ventimiglia, Leandro
A1 Fernández-Martín, Laura
A1 Martínez-Alonso, Emma
A1 Antón Hurtado, Olga María
A1 Guerra, Milagros
A1 Martínez-Menárguez, José Angel
A1 Andrés, Germán
A1 Alonso, Miguel
AB Exosomes secreted by T cells play an important role in coordinating the immune response. HIV-1 Nef hijacks the route of exosome secretion of T cells to modulate the functioning of uninfected cells. Despite the importance of the process, the protein machinery involved in exosome biogenesis is yet to be identified. In this study, we show that MAL, a tetraspanning membrane protein expressed in human T cells, is present in endosomes that travel toward the plasma membrane for exosome secretion. In the absence of MAL, the release of exosome particles and markers was greatly impaired. This effect was accompanied by protein sorting defects at multivesicular endosomes that divert the exosomal marker CD63 to autophagic vacuoles. Exosome release induced by HIV-1 Nef was also dependent on MAL expression. Therefore, MAL is a critical element of the machinery for exosome secretion and may constitute a target for modulating exosome secretion by human T cells.
PB American Association of Immunologists
SN 0022-1767
YR 2015
FD 2015
LK https://hdl.handle.net/20.500.14352/97010
UL https://hdl.handle.net/20.500.14352/97010
LA eng
NO Leandro N. Ventimiglia, Laura Fernández-Martín, Emma Martínez-Alonso, Olga M. Antón, Milagros Guerra, José Angel Martínez-Menárguez, Germán Andrés, Miguel A. Alonso; Cutting Edge: Regulation of Exosome Secretion by the Integral MAL Protein in T Cells. J Immunol 1 August 2015; 195 (3): 810–814. https://doi.org/10.4049/jimmunol.1500891
NO Comunidad de Madrid
NO Ministerio de Economía y Competitividad (España)
DS Docta Complutense
RD 23 abr 2025