RT Journal Article
T1 Nanocomposite Hydrogels as Platform for Cells Growth, Proliferation, and Chemotaxis
A1 Fiorini, Federica
A1 Prasetyanto, Eko Adi
A1 Taraballi, Francesca
A1 Pandolfi, Laura
A1 Monroy Muñoz, Francisco
A1 López-Montero, Iván
A1 Tasciotti, Ennio
A1 De Cola, Luisa
AB The challenge of mimicking the extracellular matrix with artificial scaffolds that are able to reduce immunoresponse is still unmet. Recent findings have shown that mesenchymal stem cells (MSC) infiltrating into the implanted scaffold have effects on the implant integration by improving the healing process. Toward this aim, a novel polyamidoamine-based nanocomposite hydrogel is synthesized, crosslinked with porous nanomaterials (i.e., mesoporous silica nanoparticles), able to release chemokine proteins. A comprehensive viscoelasticity study confirms that the hydrogel provides optimal structural support for MSC infiltration and proliferation. The efficiency of this hydrogel, containing the chemoattractant stromal cell-derived factor 1α (SDF-1α), in promoting MSC migration in vitro is demonstrated. Finally, subcutaneous implantation of SDF-1α-releasing hydrogels in mice results in a modulation of the inflammatory reaction. Overall, the proposed SDF-1α-nanocomposite hydrogel proves to have potential for applications in tissue engineering.
PB Wiley
SN 1613-6810
YR 2016
FD 2016
LK https://hdl.handle.net/20.500.14352/23741
UL https://hdl.handle.net/20.500.14352/23741
LA eng
NO The research leading to these results has received funding from the European Research Council under the European Union's Seventh Framework Programme (ERC grant agreement n° 338133)
NO Unión Europea. FP7
NO Ministerio de Economía y Competitividad (MINECO)
NO Comunidad de Madrid
NO Ministerio de Economía y Competitividad (MINECO)
DS Docta Complutense
RD 20 dic 2025