%0 Journal Article
%A Enríquez Rodríguez, Eduardo
%A Amat Santos, Ignacio J.
%A Jiménez Quevedo, Pilar
%A Martín Morquecho, Irene
%A Tirado Conte, Gabriela
%A Pérez-Vizcayno, María José
%A Gómez de Diego, José Juan
%A Arnold, Roman
%A Aldazábal, Andrés
%A Rojas, Paol
%A Agustín, Alberto de
%A Trigo, María Del
%A Gutiérrez, Hipólito
%A San Román, José A.
%A Macaya Miguel, Carlos
%A Nombela Franco, Luis
%T Comparison of the Hemodynamic Performance of the Balloon-expandable SAPIEN 3 Versus Self-expandable Evolut R Transcatheter Valve: A Case-matched Study
%D 2017
%U https://hdl.handle.net/20.500.14352/133626
%X Introduction and objectives: The SAPIEN 3 (S3) valve and the Medtronic Evolut R (EVR) are secondgeneration transcatheter valves, designed to further reduce the rate of paravalvular aortic regurgitation(AoR). The aim of this study was to compare the 2 devices in terms of valve performance in a casematched study with independent echocardiographic analysis.Methods: Of a population of 201 patients who underwent transcatheter aortic valve implantation,144 patients (S3, n = 80; EVR, n = 64) were matched according to aortic annulus diameter and aortic valvecalcium score, as assessed by computed tomography. All echocardiographic examinations collected atbaseline and at 1- and 6-month follow-up were centrally analyzed.Results: The 2 groups were well balanced in baseline clinical and echocardiographic characteristics. TheEVR valve showed a better hemodynamic profile as assessed by peak aortic gradient (EVR 13  7 vsS3 20  10 mmHg; P < .001), mean aortic gradient (EVR 7  3 vs S3 11  6 mmHg; P < .001), and Dopplervelocity index (EVR 0.65  0.15 vs S3 0.51  0.16; P < .001). The rate of moderate-severe or any paravalvular( mild) AoR was higher in the EVR group (11% and 50%) than in the S3 group (2.5% and 21%; P < .05,respectively), with a larger number of paravalvular jets (P < .001).Conclusions: In a case-matched cohort of transcatheter aortic valve implantation patients, the S3 valve wasassociatedwitha lower rate ofparavalvularAoR but alsowithahigher residual gradientthanthe EVRsystem.
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