RT Journal Article
T1 Abstinent patients with alcohol use disorders show an altered plasma cytokine profile: identification of both interleukin 6 and interleukin 17A as potential biomarkersof consumption and comorbid liver and pancreatic diseases
A1 García Marchena, Nuria
A1 Maza-Quiroga, Rosa
A1 Serrano, Antonia
A1 Barrios, Vicente
A1 Requena-Ocaña, Nerea
A1 Suárez, Juan
A1 Ann Chowen, Julie
A1 Argente, Jesús
A1 Rubio, Gabriel
A1 Torrens, Marta
A1 López-Gallardo, Meritxell
A1 Marco López, Eva María
A1 Castilla-Ortega, Estela
A1 Rodríguez De Fonseca, Fernando Antonio
A1 Santín, Luis Javier
A1 Pavón Carrasco, Francisco Javier
A1 Araos, Pedro
AB Background: Recent studies have demonstrated that alcohol consumption can modulate the immune system by directly activating natural immunity and triggering inflammatory processes in the central nervous system and in peripheral organs, such as the liver and pancreas. Patients with alcohol use disorders have an elevated frequency of comorbid mental disorders and gut diseases (i.e. fatty liver and pancreatitis) that complicate diagnosis, treatment and prognosis. Aims: The present study aims to explore possible associations in circulating plasma cytokine concentrations in abstinent patients diagnosed with alcohol use disorders. Methods: To this end, 85 abstinent subjects with alcohol use disorders from an outpatient setting and 55 healthy subjects were evaluated for both substance and mental disorders. The plasma levels of cytokines interleukin 1 beta, interleukin 4, interleukin 6, interleukin 17A, interferon gamma and tumour necrosis alpha were determined and their association with (a) history of alcohol consumption, (b) psychiatric comorbidity and (c) liver/ pancreas comorbidities was explored. Results:We found that plasma concentrations of interleukin 1 beta, interleukin 6 and tumour necrosis alpha were increased, whereas plasma concentrations of interleukin 4, interleukin 17A and interferon gamma were decreased in abstinent alcohol use disorder patients as compared with control subjects. Moreover, we found that changes in interleukin 6 and interleukin 17A plasma concentrations in alcohol use disorder patients were associated with the presence of liver and pancreatic diseases.Conclusion: The present results suggest alcohol use disorder is associated with alterations of plasma cytokines, being interleukin 6 and interleukin 17A potential biomarkers of the presence of comorbidities of digestive organs. The clinical relevance of these findings is discussed in the context of alcohol-induced inflammatory processes.
PB SAGE Publications
SN ESSN 1461-7285
YR 2020
FD 2020-06-13
LK https://hdl.handle.net/20.500.14352/6660
UL https://hdl.handle.net/20.500.14352/6660
LA eng
NO Ministerio de Economía y Competitividad (MINECO)/Fondo Europeo de Desarrollo Regional (FEDER)
NO Ministerio de Sanidad, Servicios Sociales e Igualdad/Fondo Europeo de Desarrollo Regional (FEDER)
NO Instituto de Salud Carlos III (ISCIII)/Fondo Europeo de Desarrollo Regional (FEDER)
NO Junta de Andalucía. Consejería de Salud y Bienestar Social/Fondo Europeo de Desarrollo Regional (FEDER)
NO Universidad de Málaga
DS Docta Complutense
RD 7 abr 2025