RT Journal Article
T1 Ciprofloxacin release and corrosion behaviour of a hybrid PEO/PCL coating on Mg3Zn0.4Ca alloy
A1 Moreno, Lara
A1 Cheng, Wang
A1 Sviatlana, Lamaka
A1 Zheludkevich, Mikhail L.
A1 Rodríguez Hernández, Juan
A1 Arrabal Durán, Raúl
A1 Matykina, Endzhe
AB In the present work, a hybrid hierarchical coating (HHC) system comprising a plasma electrolytic oxidation (PEO) coating and a homogeneously porous structured polycaprolactone (PCL) top-coat layer, loaded with ciprofloxacin (CIP), was developed on Mg3Zn0.4Ca alloy. According to the findings, the HHC system avoided burst release and ensured gradual drug elution (64% over 240 h). The multi-level protection of the magnesium alloy is achieved through sealing of the PEO coating pores by the polymer layer and the inhibiting effect of CIP (up to 74%). The corrosion inhibition effect of HHC and the eluted drug is associated with the formation of insoluble CIP-Me (Mg/Ca) chelates that repair the defects in the HHC and impede the access of corrosive species as corroborated by FTIR spectra, EIS and SEM images after 24 h of immersion. Therefore, CIP participates in an active protection mechanism by interacting with cations coming through the damaged coating
PB MDPI
YR 2023
FD 2023
LK https://hdl.handle.net/20.500.14352/109124
UL https://hdl.handle.net/20.500.14352/109124
LA eng
NO : Moreno, L.; Wang, C.; Lamaka, S.V.; Zheludkevich, M.L.; Rodríguez-Hernández, J.; Arrabal, R.; Matykina, E. Ciprofloxacin Release and Corrosion Behaviour of a Hybrid PEO/PCL Coating on Mg3Zn0.4Ca Alloy. J. Funct. Biomater. 2023, 14, 65
DS Docta Complutense
RD 7 abr 2025