RT Journal Article
T1 Magnetic-Responsive Release Controlled by Hot Spot Effect
A1 Guisasola, Eduardo
A1 Báez Rubio, Alejandro
A1 Talelli, Marina
A1 Arcos Navarrete, Daniel
A1 Moros, Maria
A1 Fuente, Jesus M. de la
A1 Vallet Regí, María Dulce Nombre
AB Magnetically triggered drug delivery nanodevices have attracted great attention in nanomedicine, as they can feature as smart carriers releasing their payload at clinician's will. The key principle of these devices is based on the properties of magnetic cores to generate thermal energy in the presence of an alternating magnetic field. Then, the temperature increase triggers the drug release. Despite this potential, the rapid heat dissipation in living tissues is a serious hindrance for their clinical application. It is hypothesized that magnetic cores could act as hot spots, this is, produce enough heat to trigger the release without the necessity to increase the global temperature. Herein, a nanocarrier has been designed to respond when the temperature reaches 43 degrees C. This material has been able to release its payload under an alternating magnetic field without the need of increasing the global temperature of the environment, proving the efficacy of the hot spot mechanism in magnetic-responsive drug delivery devices.
PB American Chemical Society
SN 0743-7463
YR 2015
FD 2015-11-04
LK https://hdl.handle.net/20.500.14352/23182
UL https://hdl.handle.net/20.500.14352/23182
LA eng
NO RESEARCHER ID K-8193-2014 (Alejandro Baeza)ORCID 0000-0002-9042-8865 (Alejandro Baeza)RESEARCHER ID E-8300-2012 (Eduardo Guisasola Cal)ORCID 0000-0002-2549-1745 (Eduardo Guisasola Cal)RESEARCHER ID M-3378-2014 (María Vallet Regí)ORCID 0000-0002-6104-4889 (María Vallet Regí)RESEARCHER ID L-6167-2014 (Daniel Arcos Navarrete)ORCID 0000-0002-5367-7272 (Daniel Arcos Navarrete)
NO Unión Europea. FP7
NO Ministerio de Economía y Competitividad (MINECO)
NO Agening Network of Excel-82 lence
NO Fondo Social Europeo (FSE)
NO CIBER
NO Instituto de Salud Carlos III
DS Docta Complutense
RD 4 abr 2025