RT Journal Article
T1 World Association for Veterinary Dermatology Consensus Statement for Diagnosis, and Evidence‐Based Clinical Practice Guidelines for Treatment and Prevention of Canine Leishmaniosis
A1 Saridomichelakis, Manolis N.
A1 Baneth, Gad
A1 Colombo, Silvia
A1 Dantas‐Torres, Filipe
A1 Ferrer, Lluís
A1 Fondati, Alessandra
A1 Miró Corrales, Guadalupe
A1 Ordeix, Laura
A1 Otranto, Domenico
A1 Noli, Chiara
AB Background: Canine leishmaniosis (CanL) due to Leishmania infantum remains common, and veterinarians do not always follow scientifically sound approaches for diagnosis, treatment and prevention.Objectives: To provide consensus guidelines for diagnosis and evidence-based guidelines for treatment and prevention of CanL.Methods and material: Clinical consensus guidelines for the diagnosis were structured based on literature and authors' experience. Three electronic databases were searched for randomised controlled trials, systematic reviews and meta-analyses on treatment and prevention.Results, conclusions and clinical importance: Diagnosis should be based on compatible clinical signs and/or clinicopathologic abnormalities, exclusion of differentials, demonstration of infection and increased concentration of anti-Leishmania IgG (quantitative serology). Euthanasia for public health purposes is not recommended and drugs with anti-Leishmania activity should be avoided in subclinically infected dogs. Recommended treatments include meglumine antimoniate-allopurinol (first-line treatment), miltefosine-allopurinol (first-line treatment) and aminosidine-allopurinol (second-line treatment); marbofloxacin may be considered in dogs with advanced chronic kidney disease. In endemic areas, recommended measures for prevention include deltamethrin 4% collar, flumethrin 4.5%-imidacloprid 10% collar or permethrin 50%-imidacloprid 10% spot-on, not using infected blood products for transfusion, not breeding seropositive bitches or dogs with CanL, administration of domperidone (seronegative dogs) and dietary nucleotides-active hexose correlated compound (subclinically infected, seropositive dogs). Vaccination with LiESP with MDP may be considered, whereas protein Q vaccine is recommended in areas with very high rates of seroconversion. In non-endemic areas, recommended measures include not using infected blood products for transfusion and removal of infected female dogs from reproductio
PB Wiley
SN 0959-4493
YR 2025
FD 2025
LK https://hdl.handle.net/20.500.14352/124004
UL https://hdl.handle.net/20.500.14352/124004
LA eng
NO Saridomichelakis, M. N., Baneth, G., Colombo, S., Dantas-Torres, F., Ferrer, L., Fondati, A., Miró, G., Ordeix, L., Otranto, D., & Noli, C. (2025). World Association for Veterinary Dermatology Consensus Statement for Diagnosis, and Evidence-Based Clinical Practice Guidelines for Treatment and Prevention of Canine Leishmaniosis. Veterinary dermatology, 10.1111/vde.70006. Advance online publication. https://doi.org/10.1111/vde.70006
NO Author Contributions:Manolis N. Saridomichelakis: data curation (lead), formal analysis(lead), investigation (lead), methodology (lead), writing – original draft(lead), writing – review and editing (lead). Gad Baneth: writing – origi-nal draft (equal), writing – review and editing (equal). Silvia Colombo:writing – original draft (equal), writing – review and editing (equal). Filipe Dantas-Torres: writing – original draft (equal), writing – re-view and editing (equal). Lluís Ferrer: writing – original draft (equal),writing – review and editing (equal). Alessandra Fondati: writing –original draft (equal), writing – review and editing (equal). GuadalupeMiró: writing – original draft (equal), writing – review and editing(equal). Laura Ordeix: investigation (supporting), writing – originaldraft (equal), writing – review and editing (equal). Domenico Otranto:writing – original draft (equal), writing – review and editing (equal).Chiara Noli: conceptualization, data curation, formal analysis, fund-ing acquisition, investigation, methodology, project administration, su-pervision, validation, writing – original draft (equal), writing – reviewand editing (equal)
DS Docta Complutense
RD 31 dic 2025