RT Journal Article T1 An update to Hippocampome.org by integrating single-cell phenotypes with circuit function in vivo A1 Sánchez-Aguilera López, Alberto A1 Wheeler, Diek W A1 Jurado Parras, Teresa A1 Valero, Manuel A1 Nokia, Miriam S. A1 Cid, Elena A1 Fernández Lamo, Iván A1 Sutton, Nate A1 García Rincón, Daniel A1 Prida, Liset M. de la AB Understanding brain operation demands linking basic behavioral traits to cell-type specific dynamics of different brain-wide subcircuits. This requires a system to classify the basic operational modes of neurons and circuits. Single-cell phenotyping of firing behavior during ongoing oscillations in vivo has provided a large body of evidence on entorhinal–hippocampal function, but data are dispersed and diverse. Here, we mined literature to search for information regarding the phase-timing dynamics of over 100 hippocampal/entorhinal neuron types defined in Hippocampome.org. We identified missing and unresolved pieces of knowledge (e.g., the preferred theta phase for a specific neuron type) and complemented the dataset with our own new data. By confronting the effect of brain state and recording methods, we highlight the equivalences and differences across conditions and offer a number of novel observations. We show how a heuristic approach based on oscillatory features of morphologically identified neurons can aid in classifying extracellular recordings of single cells and discuss future opportunities and challenges towards integrating single-cell phenotypes with circuit function. PB Plos YR 2021 FD 2021-05 LK https://hdl.handle.net/20.500.14352/95309 UL https://hdl.handle.net/20.500.14352/95309 LA eng NO Sanchez-Aguilera A, Wheeler DW, Jurado-Parras T, Valero M, Nokia MS, Cid E, Fernandez-Lamo I, Sutton N, García-Rincón D, de la Prida LM, Ascoli GA. An update to Hippocampome.org by integrating single-cell phenotypes with circuit function in vivo. PLoS Biol. 2021 May 6;19(5):e3001213. doi: 10.1371/journal.pbio.3001213. PMID: 33956790; PMCID: PMC8130934. NO National Institutes of Health NO Ministerio de Economía y Competitividad NO Academy of Finland NO European Molecular Biology Organization NO Human Frontiers Science Program DS Docta Complutense RD 6 abr 2025