RT Journal Article
T1 Infrared molecular imaging of infarcted myocardium using rare earth nanoparticles and click chemistry
A1 Didonè, Livia
A1 Gutiérrez González, Paula
A1 Qiu, Dongmei
A1 Artiga, Álvaro
A1 Ortgies, Dirk H.
A1 Román Carmena, Marta
A1 Amor, Sara
A1 García-Villalón, Angel Luis
A1 Granado, Miriam
A1 Jaque García, Daniel
A1 Villaverde Cantizano, Gonzalo
A1 Rubio Retama, Benito Jorge
AB Fluorescence imaging using antibody-functionalized luminescent nanoparticles has shown promise for in vivo imaging of infarcted tissues; however, challenges such as suboptimal antibody orientation, increased hydrodynamic size, and reduced circulation times affect their targeting efficiency, hindering their clinical application. In this study, we propose to address these limitations by combining a pretargeting strategy with the overexpression of intercellular adhesion molecule 1 (ICAM-I) in infarcted myocardium, the sharp emission lines of infrared-emitting neodymium/ytterbium co-doped nanoparticles, and hyperspectral imaging technology. The feasibility of the method is demonstrated through ex vivo experiments and autofluorescence-free imaging of beating hearts, highlighting its potential as a high-contrast, non-invasive tool for myocardial infarction diagnosis.
PB Elsevier
YR 2025
FD 2025-10-23
LK https://hdl.handle.net/20.500.14352/130794
UL https://hdl.handle.net/20.500.14352/130794
LA eng
NO Didonè L, González PG, Qiu D, et al. Infrared molecular imaging of infarcted myocardium using rare earth nanoparticles and click chemistry. Colloids and Surfaces B: Biointerfaces 2026;259:115332. https://doi.org/10.1016/j.colsurfb.2025.115332
NO Ministerio de Ciencia e Innovación (España)
NO European Commission
NO Comunidad de Madrid
NO Instituto de Salud Carlos III (España)
DS Docta Complutense
RD 10 abr 2026