%0 Journal Article
%A Rodríguez Grande, Cristina
%A Estévez, Agustín
%A Palomino Cabrera, Rosalía
%A Molero Salinas, Andrea
%A Peñas Utrilla, Daniel
%A Herranz, Marta
%A Sanz Pérez, Amadeo
%A Alcalá, Luis
%A Veintimilla, Cristina
%A Catalán Alonso, Pilar
%A Martínez Laperche, Carolina
%A Alonso Fernández, Roberto Alfonso
%A Muñoz García, Patricia Carmen
%A Pérez Lago, Laura
%A Viedma, Darío García de
%A Burillo Albizua, Almudena
%T Early SARS-CoV-2 Reinfections Involving the Same or Different Genomic Lineages, Spain
%D 2023
%@ 1080-6040
%@ 1080-6059
%U https://hdl.handle.net/20.500.14352/130201
%X Centers for Disease Control and Prevention guidelines consider SARS-CoV-2 reinfection when sequential COVID-19 episodes occur >90 days apart. However, genomic diversity acquired over recent COVID-19 waves could mean previous infection provides insufficient cross-protection. We used genomic analysis to assess the percentage of early reinfections in a sample of 26 patients with 2 COVID-19 episodes separated by 20–45 days. Among sampled patients, 11 (42%) had reinfections involving different SARS-CoV-2 variants or subvariants. Another 4 cases were probable reinfections; 3 involved different strains from the same lineage or sublineage. Host genomic analysis confirmed the 2 sequential specimens belonged to the same patient. Among all reinfections, 36.4% involved non-Omicron, then Omicron lineages. Early reinfections showed no specific clinical patterns; 45% were among unvaccinated or incompletely vaccinated persons, 27% were among persons <18 years of age, and 64% of patients had no risk factors. Time between sequential positive SARS-CoV-2 PCRs to consider reinfection should be re-evaluated.
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