RT Journal Article
T1 Early SARS-CoV-2 Reinfections Involving the Same or Different Genomic Lineages, Spain
A1 Rodríguez Grande, Cristina
A1 Estévez, Agustín
A1 Palomino Cabrera, Rosalía
A1 Molero Salinas, Andrea
A1 Peñas Utrilla, Daniel
A1 Herranz, Marta
A1 Sanz Pérez, Amadeo
A1 Alcalá, Luis
A1 Veintimilla, Cristina
A1 Catalán Alonso, Pilar
A1 Martínez Laperche, Carolina
A1 Alonso Fernández, Roberto Alfonso
A1 Muñoz García, Patricia Carmen
A1 Pérez Lago, Laura
A1 Viedma, Darío García de
A1 Burillo Albizua, Almudena
AB Centers for Disease Control and Prevention guidelines consider SARS-CoV-2 reinfection when sequential COVID-19 episodes occur >90 days apart. However, genomic diversity acquired over recent COVID-19 waves could mean previous infection provides insufficient cross-protection. We used genomic analysis to assess the percentage of early reinfections in a sample of 26 patients with 2 COVID-19 episodes separated by 20–45 days. Among sampled patients, 11 (42%) had reinfections involving different SARS-CoV-2 variants or subvariants. Another 4 cases were probable reinfections; 3 involved different strains from the same lineage or sublineage. Host genomic analysis confirmed the 2 sequential specimens belonged to the same patient. Among all reinfections, 36.4% involved non-Omicron, then Omicron lineages. Early reinfections showed no specific clinical patterns; 45% were among unvaccinated or incompletely vaccinated persons, 27% were among persons <18 years of age, and 64% of patients had no risk factors. Time between sequential positive SARS-CoV-2 PCRs to consider reinfection should be re-evaluated.
PB GA Centers for Disease Control and Prevention
SN 1080-6040
SN 1080-6059
YR 2023
FD 2023-05-02
LK https://hdl.handle.net/20.500.14352/130201
UL https://hdl.handle.net/20.500.14352/130201
LA eng
NO Rodríguez-Grande, C., Estévez, A., Palomino-Cabrera, R., Molero-Salinas, A., Peñas-Utrilla, D., Herranz, M....de Viedma, D. (2023). Early SARS-CoV-2 Reinfections Involving the Same or Different Genomic Lineages, Spain. Emerging Infectious Diseases, 29(6), 1154-1161. https://doi.org/10.3201/eid2906.221696.
NO La investigadora Almudena Burillo pertenece a Gregorio Marañón Microbiology-ID COVID 19 Study Group y realiza su aportación como autora colaboradora.Fondo Europeo de Desarrollo Regional (FEDER) – A way of making EuropeEuropean Centre for Disease Prevention and Control (ECDC)
NO Instituto de Salud Carlos III
NO Unión Europea
NO Instituto de Investigación Sanitaria Gregorio Marañón
DS Docta Complutense
RD 19 ene 2026