RT Journal Article
T1 New melatonin–cinnamate hybrids as multi-target drugs for neurodegenerative diseases: Nrf2-induction, antioxidant effect and neuroprotection
A1 Buendia, Izaskun
A1 Navarro González De Mesa, Elisa
A1 Michalska Dziama, Patrycja
A1 Gameiro, Isabel
A1 Egea, Javier
A1 Abril, Sheila
A1 López, Alicia
A1 González-Lafuente, Laura
A1 G. López, Manuela
A1 León Martínez, Rafael
AB Neurodegenerative diseases share many pathological pathways, such as abnormal protein aggregation, mitochondrial dysfunction, extensive oxidative stress and neuroinflammation. Cells have an intrinsic mechanism of protection, the Nrf2 transcriptional factor, known as the master regulator of redox homeostasis. Results: Based on the common features of these diseases we have designed a multi-target hybrid structure derived from melatonin and ethyl cinnamate. The obtained derivatives were Nrf2 inducers and potent-free radical scavengers. These new compounds showed a very interesting neuroprotective profile in several in vitro models of oxidative stress, Alzheimer's disease and brain ischemia. Conclusion: We have designed a new hybrid structure with complementary activities. We have identified compound 5h as an interesting Nrf2 inducer, very potent antioxidant and neuroprotectant.
SN 1756-8919
YR 2015
FD 2015-10-23
LK https://hdl.handle.net/20.500.14352/97103
UL https://hdl.handle.net/20.500.14352/97103
LA eng
NO European Commission
NO Ministerio de Sanidad(España)
NO Ministerio de Economía, Comercio y Empresa(España)
NO Instituto de Salud Carlos III
NO Ministerio de Educación, Cultura y Deporte(España)
DS Docta Complutense
RD 23 ago 2024