RT Journal Article
T1 “GENYAL” Study to Childhood Obesity Prevention: Methodology and Preliminary Results
A1 Marcos-Pasero, Helena
A1 Aguilar-Aguilar, Elena
A1 Iglesia, Rocío de la
A1 Espinosa-Salinas, Isabel
A1 Molina, Susana
A1 Colmenarejo, Gonzalo
A1 Martínez, J. Alfredo
A1 Ramírez de Molina, Ana
A1 Reglero, Guillermo
A1 Loria Kohen, Viviana Constanza
AB Objective: This article describes the methodology and summarizes some preliminary results of the GENYAL study aiming to design and validate a predictive model, considering both environmental and genetic factors, that identifies children who would benefit most from actions aimed at reducing the risk of obesity and its complications. Design: The study is a cluster randomized clinical trial with 5-year follow-up. The initial evaluation was carried out in 2017. The schools were randomly split into intervention (nutritional education) and control schools. Anthropometric measurements, social and health as well as dietary and physical activity data of schoolchildren and their families are annually collected. A total of 26 single nucleotide polymorphisms (SNPs) were assessed. Machine Learning models are being designed to predict obesity phenotypes after the 5-year follow-up. Settings: Six schools in Madrid. Participants: A total of 221 schoolchildren (6-8 years old). Results: Collected results show that the prevalence of excess weight was 19.0, 25.4, and 32.2% (according to World Health Organization, International Obesity Task Force and Orbegozo Foundation criteria, respectively). Associations between the nutritional state of children with mother BMI [β = 0.21 (0.13-0.3), p (adjusted) <0.001], geographical location of the school [OR = 2.74 (1.24-6.22), p (adjusted) = 0.06], dairy servings per day [OR = 0.48 (0.29-0.75), p (adjusted) = 0.05] and 8 SNPs [rs1260326, rs780094, rs10913469, rs328, rs7647305, rs3101336, rs2568958, rs925946; p (not adjusted) <0.05] were found. Conclusions: These baseline data support the evidence that environmental and genetic factors play a role in the development of childhood obesity. After 5-year follow-up, the GENYAL study pretends to validate the predictive model as a new strategy to fight against obesity.
PB Frontiers
SN 2296-861X
YR 2022
FD 2022
LK https://hdl.handle.net/20.500.14352/104162
UL https://hdl.handle.net/20.500.14352/104162
LA eng
NO Marcos-Pasero H, Aguilar-Aguilar E, de la Iglesia R, Espinosa-Salinas I, Molina S, Colmenarejo G, Martínez JA, Ramírez de Molina A, Reglero G, Loria-Kohen V. "GENYAL" Study to Childhood Obesity Prevention: Methodology and Preliminary Results. Front Nutr. 2022 Mar 8;9:777384.
NO Clinical Trial Registration: This study has been registered in ClinicalTrials.gov with the identifier NCT03419520, https://clinicaltrials.gov/ct2/show/NCT03419520.
NO Conserjería de Educación, Universidades y Ciencia de la Comunidad de Madrid, Dirección General de Educación Infantil, Primaria y Secundaria.
DS Docta Complutense
RD 18 dic 2025