RT null
T1 The potential use of tetracyclines in neurodegenerative diseases and the role of nano-based drug delivery systems
A1 Rahmani, Mahdieh
A1 Negro Álvarez, María Sofía Elisa
A1 Barcia Hernández, Emilia María
AB Neurodegenerative diseases are still a challenge for effective treatments. The high cost of approved drugs, severity of side effects, injection site pain, and restrictions on drug delivery to the Central Nervous System (CNS) can overshadow the management of these diseases. Due to the chronic and progressive evolution of neurodegenerative disorders and since there is still no cure for them, new therapeutic strategies such as the combination of several drugs or the use of existing drugs with new therapeutic applications are valuable strategies. Tetracyclines are traditionally classified as antibiotics. However, in this class of drugs, doxycycline and minocycline exhibit also anti-inflammatory effects by inhibiting microglia/macrophages. Hence, they have been studied as potential agents for the treatment of neurodegenerative diseases. The results of in vitro and in vivo studies confirm the effective role of these two drugs as anti-inflammatory agents in experimentally induced models of neurodegenerative diseases. In clinical studies, satisfactory results have been obtained in Multiple sclerosis (MS) but not yet in other disorders such as Alzheimer's disease (AD), Parkinson's disease (PD), or Amyotrophic lateral sclerosis (ALS). In recent years, researchers have developed and evaluated nanoparticulate drug delivery systems to improve the clinical efficacy of these two tetracyclines for their potential application in neurodegenerative diseases. This study reviews the neuroprotective roles of minocycline and doxycycline in four of the main neurodegenerative disorders: AD, PD, ALS and MS. Moreover, the potential applications of nanoparticulate delivery systems developed for both tetracyclines are also reviewed.
PB Elsevier
YR 2022
FD 2022-06-13
LK https://hdl.handle.net/20.500.14352/125309
UL https://hdl.handle.net/20.500.14352/125309
LA eng
NO Rahmani, Mahdieh & Negro Alvarez, Maria & Barcia, Emilia. (2022). The potential use of tetracyclines in neurodegenerative diseases and the role of nano-based drug delivery systems. European Journal of Pharmaceutical Sciences. 175. 106237. 10.1016/j.ejps.2022.106237.
NO Mahdieh Rahmani: Investigation, Methodology, Validation, Visualization,Writing – original draft. Sofía Elisa Negro ´Alvarez: Conceptualization,Supervision, Writing – review & editing. Emilia BarciaHern´andez: Conceptualization, Supervision, Writing – review &editing.
DS Docta Complutense
RD 18 dic 2025