RT Journal Article
T1 Neural-derived estradiol regulates brain plasticity
A1 Azcoitia Elías, Iñigo
A1 Arévalo, María Ángeles
A1 García Segura, Luis Miguel
AB In addition to be an ovarian hormone, estradiol is a neurosteroid synthesized by neural cells. The brain is a steroidogenic tissue that metabolizes testosterone to estradiol. The last step in the synthesis of estradiol is catalyzed by the enzyme aromatase, which is widely expressed in the brain of male and female animals and humans. Studies that have manipulated the expression or the activity of aromatase have revealed that brain-derived estradiol acts as a neuromodulator and regulates different forms of brain plasticity in male and female animals. The regulation of neuroplastic events by brain-derived estradiol probably participates in the effects of brain aromatase on behavior and cognition.
PB Elsevier
SN 0891-0618
YR 2016
FD 2016
LK https://hdl.handle.net/20.500.14352/23477
UL https://hdl.handle.net/20.500.14352/23477
LA eng
NO Ministerio de Economía y Competitividad (MINECO)
NO CIBERFES
DS Docta Complutense
RD 10 abr 2025