RT Journal Article
T1 Cannabidiol reduces brain damage and improves functional recovery after acute hypoxia-ischemia in newborn pigs
A1 Lafuente, Héctor
A1 Alvarez, Francisco J.
A1 Pazos, M. Ruth
A1 Alvarez, Antonia
A1 Rey-Santano, M. Carmen
A1 Mielgo, Victoria
A1 Murgia Esteve, Xavier
A1 Hilario, Enrique
A1 Martínez Orgado, José Antonio
AB Newborn piglets exposed to acute hypoxia-ischemia (HI) received i.v. cannabidiol (HI + CBD) or vehicle (HI + VEH). In HI + VEH, 72 h post-HI brain activity as assessed by amplitude-integrated EEG (aEEG) had only recovered to 42 ± 9% of baseline, near-infrared spectroscopy (NIRS) parameters remained lower than normal, and neurobehavioral performance was abnormal (27.8 ± 2.3 points, normal 36). In the brain, there were fewer normal and more pyknotic neurons, while astrocytes were less numerous and swollen. Cerebrospinal fluid concentration of neuronal-specific enolase (NSE) and S100β protein and brain tissue percentage of TNFα(+) cells were all higher. In contrast, in HI + CBD, aEEG had recovered to 86 ± 5%, NIRS parameters increased, and the neurobehavioral score normalized (34.3 ± 1.4 points). HI induced histological changes, and NSE and S100β concentration and TNFα(+) cell increases were suppressed by CBD. In conclusion, post-HI administration of CBD protects neurons and astrocytes, leading to histological, functional, biochemical, and neurobehavioral improvements.
PB Nature
YR 2011
FD 2011
LK https://hdl.handle.net/20.500.14352/117040
UL https://hdl.handle.net/20.500.14352/117040
LA eng
NO Lafuente H, Alvarez FJ, Pazos MR, Alvarez A, Rey-Santano MC, Mielgo V, Murgia-Esteve X, Hilario E, Martinez-Orgado J. Cannabidiol reduces brain damage and improves functional recovery after acute hypoxia-ischemia in newborn pigs. Pediatr Res. 2011 Sep;70(3):272-7. doi: 10.1203/PDR.0b013e3182276b11. PMID: 21654550.
DS Docta Complutense
RD 16 abr 2025