RT Journal Article
T1 Oxidative Stress in Canine Diseases: A Comprehensive Review
A1 Pérez Montero, Blanca
A1 Fermín Rodríguez, María Luisa
A1 Miró Corrales, Guadalupe
A1 Cruz López, Fátima
AB Oxidative stress (OS), defined as a disruption in redox balance favoring oxidants, has emerged as a major contributor to numerous diseases in human and veterinary medicine. While several reviews have explored the implication of OS in human pathology, an exhaustive review of the canine species is lacking. This comprehensive review aims to summarize the existing literature on the role of OS in canine diseases, highlighting its potentially detrimental effect on various organs and systems. Some inconsistencies among studies exist, likely due to varying biomarkers and sample types. However, there is substantial evidence supporting the involvement of OS in the development or progression of numerous canine disorders, such as cardiovascular, oncologic, endocrine, gastrointestinal, hematologic, renal, neurologic, infectious, and parasitic diseases, among others. Additionally, this review discusses the efficacy of antioxidant and pro-oxidant therapeutic agents for these conditions. Dietary interventions to counteract OS in dogs have gained significant attention in recent years, although further research on the topic is needed. This review aims to serve as a foundational resource for future investigations in this promising field.
PB MDPI
YR 2024
FD 2024
LK https://hdl.handle.net/20.500.14352/112165
UL https://hdl.handle.net/20.500.14352/112165
LA eng
NO Blanca, P.-M.; María Luisa, F.-R.; Guadalupe, M.; Fátima, C.-L. Oxidative Stress in Canine Diseases: A Comprehensive Review. Antioxidants 2024, 13, 1396. https:// doi.org/10.3390/antiox13111396
NO Justificación de autores:Conceptualization, P.-M.B. and C.-L.F.; methodology, P.-M.B. and C.-L.F.; software, P.-M.B. and C.-L.F.; validation, P.-M.B., F.-R.M.L., M.G. and C.-L.F.; formal analysis, P.-M.B., F.-R.M.L., M.G. and C.-L.F.; investigation, P.-M.B. and C.-L.F.; resources, P.-M.B., F.-R.M.L., M.G. and C.-L.F.; data curation, P.-M.B. and C.-L.F.; writing—original draft preparation, P.-M.B.; writing—review and editing, P.-M.B., F.-R.M.L., M.G. and C.-L.F.; visualization, P.-M.B. and C.-L.F.; supervision, M.G. and C.-L.F.; project administration, M.G. and C.-L.F.; funding acquisition, M.G. and C.-L.F. All authors have read and agreed to the published version of the manuscript.
DS Docta Complutense
RD 6 abr 2025