%0 Journal Article
%A Loma Lozano, Patricia
%A Guzmán Aránguez, Ana Isabel
%A Pérez de Lara, María Jesús
%A Pintor, Jesús
%T Lactoferrin Levels in Tears are Increased by the Topical Application of Diadenosine Tetraphosphate
%D 2016
%@ 0271-3683
%U https://hdl.handle.net/20.500.14352/17684
%X Purpose: This study was undertaken to determine the effect of the topical application of diadenosine tetraphosphate on lactoferrin levels in rabbit tears.Methods: Diadenosine tetraphosphate was topically instilled in a single-dose, tear samples were collected by micropipette and lactoferrin was measured by Enzyme-Linked ImmunoSorbent Assay (ELISA).Results: The concentration of lactoferrin in rabbit tears was significantly increased 1 h after diadenosine tetraphosphate application, remaining elevated for 3 h more. This effect was blocked by P2 receptors antagonists.Conclusions: Topical application of diadenosine tetraphosphate stimulates the secretion of lactoferrin in rabbit tears through P2 receptor activation.
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