RT Journal Article
T1 Lactoferrin Levels in Tears are Increased by the Topical Application of Diadenosine Tetraphosphate
A1 Loma Lozano, Patricia
A1 Guzmán Aránguez, Ana Isabel
A1 Pérez de Lara, María Jesús
A1 Pintor, Jesús
AB Purpose: This study was undertaken to determine the effect of the topical application of diadenosine tetraphosphate on lactoferrin levels in rabbit tears.Methods: Diadenosine tetraphosphate was topically instilled in a single-dose, tear samples were collected by micropipette and lactoferrin was measured by Enzyme-Linked ImmunoSorbent Assay (ELISA).Results: The concentration of lactoferrin in rabbit tears was significantly increased 1 h after diadenosine tetraphosphate application, remaining elevated for 3 h more. This effect was blocked by P2 receptors antagonists.Conclusions: Topical application of diadenosine tetraphosphate stimulates the secretion of lactoferrin in rabbit tears through P2 receptor activation.
PB Taylor & Francis
SN 0271-3683
YR 2016
FD 2016-09
LK https://hdl.handle.net/20.500.14352/17684
UL https://hdl.handle.net/20.500.14352/17684
LA eng
NO Received 20 July 2015 ; Revised 8 October 2015 ; Accepted 18 October 2015
NO Ministerio de Ciencia e Innovación (MICINN)
NO RETICS (Redes Temáticas de Investigación Cooperativa en Salud)
DS Docta Complutense
RD 5 may 2024