RT Journal Article
T1 The response of pre-osteoblasts and osteoclasts to gallium containing mesoporous bioactive glasses.
A1 Gómez Cerezo, María Natividad
A1 Verron, E
A1 Montouillout, V
A1 Fayon, F
A1 Lagadec, P
A1 Bouler, J.M.
A1 Bujoli, B
A1 Arcos Navarrete, Daniel
A1 Vallet Regí, María Dulce Nombre
AB Mesoporous bioactive glasses (MBGs) in the system SiO2-CaO-P2O5-Ga2O3 have been synthesized by the evaporation induced self-assembly method and subsequent impregnation with Ga cations. Two different compositions have been prepared and the local environment of Ga(III) has beencharacterized using 29Si, 71Ga and 31P NMR analysis, demonstrating that Ga(III) is efficiently incorporated as both, network former (GaO4 units) and network modifier (GaO6 units). In vitro bioactivity tests evidenced that Ga-containing MBGs retain their capability for nucleation and growth of an apatite-like layer in contact with a simulated body fluid with ion concentrations nearly equal to those of human blood plasma. Finally, in vitro cell culture tests evidenced that Ga incorporation results in a selective effect on osteoblasts and osteoclasts. Indeed, the presence of this element enhances the early differentiation towards osteoblast phenotype while disturbing osteoclastogenesis. Considering these results, Ga-doped MBGs might be proposed as bone substitutes, especially in osteoporosis scenarios.
PB Elsevier
SN 1742-7061
YR 2018
FD 2018-06-30
LK https://hdl.handle.net/20.500.14352/12205
UL https://hdl.handle.net/20.500.14352/12205
LA eng
NO RESEARCHER ID L-6167-2014 (Daniel Arcos Navarrete)ORCID 0000-0002-5367-7272 (Daniel Arcos Navarrete)RESEARCHER ID M-3378-2014 (María Vallet Regí)ORCID 0000-0002-6104-4889 (María Vallet Regí)
NO Unión Europea. H2020
NO Ministerio de Economía y Competitividad (MINECO)
NO Fondo Europeo de Desarrollo Regional (FEDER)
DS Docta Complutense
RD 1 may 2024