RT Journal Article
T1 Stability of carboplatin infusion solutions used in desensitization protocol
A1 Vázquez-Sánchez, Rocío
A1 Sánchez-Rubio-Ferrández, Javier
A1 Córdoba Díaz, Damián
A1 Córdoba Díaz, Manuel
A1 Molina-Garcia, Teresa
AB Carboplatin hypersensitivity reactions are one of the major clinical challenges in treating patients with relapse/recurrentovarian malignancies. Desensitization protocols allow the continuation of treatment in patients who have presentedhypersensitivity reactions by gradually re-introducing small amounts of the drug up to full therapeutic doses. Carboplatindesensitization protocol is based on three solutions that are usually prepared in the chemotherapy centralized units ofhospital pharmacies. First and second solutions are diluted under the established concentration limit to guarantee thestability of the preparation. We developed a specific high-performance liquid chromatography assay to determine thestability of carboplatin infusion solutions that have been diluted to 0.2 mg/mL and 0.02 mg/mL in 250 mL of 5% dextrose inpolypropylene infusion bags which were stored 24 h protected from light at room temperature. Samples were withdrawnat t ¼ 0 h, 3 h, 6 h, and 24 h. The analytical column was a Zorbax eclipse XDB-C18 (150 mm 4.6 mm; 5 mmparticle size). The mobile phase had a flow rate of 1 mL/min under isocratic conditions of water–methanol (98:2, v/v).For 0.2 mg/mL solution, the high-performance liquid chromatography assay revealed no significant losses in carboplatinconcentration. However, in 0.02 mg/mL solution remaining carboplatin was > 105% the initial dose after 3 h of storage atroom temperature. The ultraviolet–visible spectra analysis showed that carboplatin remained intact during the study in0.2 mg/mL solution, but some changes were detected in 0.02 mg/mL solution. Thus, 0.2 mg/mL carboplatin solution isstable for 24 h at room temperature in 5% dextrose polypropylene infusion bags but stability could not be proved for0.02 mg/mL solution.
PB SAGE
SN 1078-1552
YR 2019
FD 2019
LK https://hdl.handle.net/20.500.14352/115518
UL https://hdl.handle.net/20.500.14352/115518
LA eng
NO Vázquez-Sánchez R, Sánchez-Rubio-Ferrández J, Córdoba-Díaz D, Córdoba-Díaz M, Molina-Garcia T. Stability of carboplatin infusion solutions used in desensitization protocol. Journal of Oncology Pharmacy Practice. 2019;25(5):1076-1081. doi:10.1177/1078155218772885
DS Docta Complutense
RD 4 abr 2025