RT Journal Article
T1 Estrogen receptor beta and G protein-coupled estrogen receptor 1 are involved in the acute estrogenic regulation of arginine-vasopressin immunoreactive levels in the supraoptic and paraventricular hypothalamic nuclei of female rats
A1 Lagunas García, Luisa Natalia
A1 Marraudino, Marilena
A1 Amorim, Miguel de
A1 Pinos, Helena
A1 Collado, Paloma
A1 Panzica, GianCarlo
A1 Garcia-Segura, Luis
A1 Grassi, Daniela
AB The ovarian hormone 17β-estradiol is known to regulate the release, expression and immunoreactivity of arginine-vasopressin (AVP) in the supraoptic and paraventricular hypothalamic nuclei of rodents. Previous studies have shown that estrogen receptor α is involved in the effects of chronic estradiol administration on arginine-vasopressin immunoreactivity in the female rat hypothalamus. In this study we have examined the effect of an acute administration of estradiol or specific agonists for estrogen receptors α, β and G protein-coupled estrogen receptor 1 on the immunoreactivity of arginine-vasopressin in the hypothalamus of adult ovariectomized female rats. Acute estradiol administration resulted in a significant decrease in the number of arginine-vasopressin immunoreactive neurons in the supraoptic and paraventricular nuclei after 24 h. The effects of the specific estrogen receptors agonists suggest that the action of estradiol on arginine-vasopressin immunoreactivity is mediated in the supraoptic nucleus by G protein-coupled estrogen receptor 1 and in the paraventricular nucleus by both estrogen receptor β and G protein-coupled estrogen receptor 1. Thus, in contrast to previous studies on the effect of chronic estrogenic treatments, the present findings suggest that estrogen receptor β and G protein-coupled estrogen receptor 1 mediate the acute effects of estradiol on arginine-vasopressin immunoreactivity in the hypothalamus of ovariectomized rats.
PB Elsevier
SN 0006-8993
YR 2019
FD 2019
LK https://hdl.handle.net/20.500.14352/95192
UL https://hdl.handle.net/20.500.14352/95192
LA eng
NO Lagunas, Natalia, et al. «Estrogen Receptor Beta and G Protein-Coupled Estrogen Receptor 1 Are Involved in the Acute Estrogenic Regulation of Arginine-Vasopressin Immunoreactive Levels in the Supraoptic and Paraventricular Hypothalamic Nuclei of Female Rats». Brain Research, vol. 1712, junio de 2019, pp. 93-100. https://doi.org/10.1016/j.brainres.2019.02.002.
DS Docta Complutense
RD 13 abr 2025