RT Journal Article
T1 Gene Influence in the Effectiveness of Plant Sterols Treatment in Children: Pilot Interventional Study
A1 San Mauro Martín, Ismael
A1 Garicano Vilar, Elena
A1 Sanz Rojo, Sara
A1 Collado Yurrita, Luis Rodolfo
A1 Pérez Arruche, Eva
A1 Arce Delgado, Esperanza
A1 Blumenfeld Olivares, Javier Andrés
AB Cardiovascular disease is linked to high serum low density lipoprotein (LDL)-cholesterol levels. Cardiovascular risk may be indirectly influenced by genetic load. Serum LDL-cholesterol levels may be reduced by the consumption of food enriched with plant sterols (PS). The aim was to test a plant sterol treatment on cholesterol levels according to different genetic polymorphisms. A pilot interventional trial was performed in 26 children (n = 16 girls, n = 10 boys). Seven hundred milliliters/day of commercial skimmed milk with added plant sterols delivering 2.2 g plant sterols were ingested for three weeks. Blood draws were performed at the baseline and end of the study. Significant modifications of non-high density lipoprotein (HDL)-cholesterol (p = 0.010; p = 0.013) and LDL-cholesterol (p = 0.004; p = 0.013) levels appeared in the genes LIPC C-514T and PPAR-α L162V carriers. No statistically significant differences were observed for other genes. LIPC C-514T and PPAR-alpha L162V carriers could benefit from a plant sterol supplement to ameliorate hypercholesterolemia.
PB MDPI
SN 2072-6643
YR 2019
FD 2019-10-21
LK https://hdl.handle.net/20.500.14352/12584
UL https://hdl.handle.net/20.500.14352/12584
LA eng
DS Docta Complutense
RD 7 abr 2025