RT Journal Article
T1 Characterization of Ageing- and Diet-Related Swine Models of Sarcopenia and Sarcopenic Obesity
A1 Garcia-Contreras, Consolacion
A1 Vázquez Gómez, Marta
A1 Torres-Rovira, Laura
A1 Gonzalez, Jorge
A1 Porrini, Esteban
A1 Gonzalez-Colaço, Magali
A1 Isabel Redondo, Beatriz
A1 Astiz, Susana
A1 González Bulnes, Antonio
AB Sarcopenia and sarcopenic obesity are currently considered major global threats for health and well-being. However, there is a lack of adequate preclinical models for their study. The present trial evaluated the suitability of aged swine by determining changes in adiposity, fatty acids composition, antioxidant status and lipid peroxidation, development of metabolic disturbances and structural changes in tissues and organs. Iberian sows with clinical evidence of aging-related sarcopenia were fed a standard diet fulfilling their maintenance requirements or an obesogenic diet for 100 days. Aging and sarcopenia were related to increased lipid accumulation and cellular dysfunction at both adipose tissue and non-adipose ectopic tissues (liver and pancreas). Obesity concomitant to sarcopenia aggravates the condition by increasing visceral adiposity and causing dyslipidemia, insulin resistance and lipotoxicity in non-adipose tissues. These results support that the Iberian swine model represents certain features of sarcopenia and sarcopenic obesity in humans, paving the way for future research on physiopathology of these conditions and possible therapeutic targets.
PB MDPI
SN 1422-0067
YR 2018
FD 2018-03-12
LK https://hdl.handle.net/20.500.14352/12518
UL https://hdl.handle.net/20.500.14352/12518
LA eng
NO European Cooperation in Science and Technology (EU COST)
NO Ministerio de Economía y Competitividad (MINECO)/Programa Ramón y Cajal
DS Docta Complutense
RD 27 abr 2024