RT Journal Article
T1 Polyphenols and IUGR Pregnancies: Effects of the Antioxidant Hydroxytyrosol on the Hippocampus Proteome in a Porcine Model
A1 Yeste, Natalia
A1 Pérez Valle, Jorge
A1 Vázquez Gómez, Marta
A1 Garcia Contreras, Consolación
A1 González Bulnes, Antonio
A1 Bassols, Anna
AB Supplementation of a mother’s diet with antioxidants such as hydroxytyrosol (HTX) has been proposed to ameliorate the adverse phenotypes of foetuses affected by intrauterine growth restriction (IUGR). Our previous studies showed, in a porcine model of IUGR, an effect of maternal HTX supplementation on the neurotransmitter profile of several brain areas and the morphology of the hippocampus in 100 days old foetuses. The present study analyzed the impact of maternal HTX supplementation on the hippocampus proteome at this foetal age by TMT10plex labelling. Eleven differentially abundant proteins were identified by comparing both conditions, and eight of them downregulated and three upregulated in the HTX-treated group. The downregulated proteins were mainly involved in protein synthesis and RNA metabolism and may explain the differences in neuron differentiation in the HTX-treated group. The upregulated proteins were related to cell detoxification and could represent a potential mechanism to explain the neuroprotective effect of HTX.
PB MPDI
SN 2076-3921
YR 2022
FD 2022-06-09
LK https://hdl.handle.net/20.500.14352/73221
UL https://hdl.handle.net/20.500.14352/73221
LA eng
NO Ministerio de Ciencia, Innovación y Universidades (MCIU)/FEDER
NO Spanish FPU National Program Grant (Ministry of Science, Innovation and Universities)
NO FPI National Program Grant
DS Docta Complutense
RD 8 may 2024