RT Journal Article
T1 Bovine whey peptides transit the intestinal barrier to reduce oxidative stress in muscle cells
A1 Corrochano, Alberto R.
A1 Ferraretto, Anita
A1 Arranz Gutiérrez, Elena María
A1 Stuknyte, Milda
A1 Bottani, Michela
A1 O´Connor, Paula M
A1 Kelly, Phil M
A1 De Noni, Ivano
A1 Buckin, Vitaly
A1 Giblin, Linda
AB Health benefits are routinely attributed to whey proteins, their hydrolysates and peptides based on in vitro chemical and cellular assays. The objective of this study was to track the fate of whey proteins through the upper gastrointestinal tract, their uptake across the intestinal barrier and then assess the physiological impact to downstream target cells. Simulated gastrointestinal digestion (SGID) released a selection of whey peptides some of which were transported across a Caco-2/HT-29 intestinal barrier, inhibited free radical formation in muscle and liver cells. In addition, SGID of β-lactoglobulin resulted in the highest concentration of free amino acids (176 nM) arriving on the basolateral side of the co-culture with notable levels of branched chain and sulphur-containing amino acids. In vitro results indicate that consumption of whey proteins will deliver bioactive peptides to target cells.
PB Elsevier
SN 0308-8146
YR 2019
FD 2019
LK https://hdl.handle.net/20.500.14352/96923
UL https://hdl.handle.net/20.500.14352/96923
LA eng
NO Corrochano, A. R., Ferraretto, A., Arranz, E., Stuknytė, M., Bottani, M., O'Connor, P. M., ... & Giblin, L. (2019). Bovine whey peptides transit the intestinal barrier to reduce oxidative stress in muscle cells. Food chemistry, 288, 306-314.
NO Irish Department of Agriculture, Food and the Marine
DS Docta Complutense
RD 23 ene 2026