TY  - JOUR
AU  - González-Ruiz, Víctor
AU  - Pascua, Irene
AU  - Fernández Marcelo, Tamara
AU  - Ribelles, Pascual
AU  - Bianchini, Giulia
AU  - Sridharan, Vellaisamy
AU  - Iniesta Serrano, María Pilar
AU  - Ramos García, María Teresa
AU  - Olives Barba, Ana Isabel
AU  - Martín Carmona, María Antonia
AU  - Menéndez Ramos, José Carlos
PY  - 2014
DO  - 10.1371/journal.pone.0095998
SN  - 1932-6203
UR  - https://hdl.handle.net/20.500.14352/112563
T2  - PLoS One
AB  - Topoisomerase 1 inhibition is an important strategy in targeted cancer chemotherapy. The drugs currently in use acting on this enzyme belong to the family of the camptothecins, and suffer severe limitations because of their low stability, which is...
LA  - eng
M2  - 1
PB  - PLoS
TI  - B-Ring-Aryl Substituted Luotonin A Analogues with a New Binding Mode to the Topoisomerase 1-DNA Complex Show Enhanced Cytotoxic Activity
TY  - journal article
VL  - 9
ER  -