RT Journal Article
T1 Brain oscillatory complexity across the life span
A1 Fernández Lucas, Alberto Amable
A1 Zuluaga Arias, María del Pilar
A1 Abásolo, Daniel
A1 Gómez, Carlos
A1 Serra González, Anahí María
A1 Méndez, María Andreína
A1 Hornero, Roberto
AB ObjectiveConsidering the increasing use of complexity estimates in neuropsychiatric populations, a normative study is critical to define the ‘normal’ behaviour of brain oscillatory complexity across the life span.MethodThis study examines changes in resting-state magnetoencephalogram (MEG) complexity – quantified with the Lempel–Ziv complexity (LZC) algorithm – due to age and gender in a large sample of 222 (100 males/122 females) healthy participants with ages ranging from 7 to 84 years.ResultsA significant quadratic (curvilinear) relationship (p < 0.05) between age and complexity was found, with LZC maxima being reached by the sixth decade of life. Once that peak was crossed, complexity values slowly decreased until late senescence. Females exhibited higher LZC values than males, with significant differences in the anterior, central and posterior regions (p < 0.05).ConclusionsThese results suggest that the evolution of brain oscillatory complexity across the life span might be considered a new illustration of a ‘normal’ physiological rhythm.SignificancePrevious and forthcoming clinical studies using complexity estimates might be interpreted from a more complete and dynamical perspective. Pathologies not only cause an ‘abnormal’ increase or decrease of complexity values but they actually ‘break’ the ‘normal’ pattern of oscillatory complexity evolution as a function of age.
PB Elsevier
SN 1388-2457
YR 2012
FD 2012-11
LK https://hdl.handle.net/20.500.14352/44606
UL https://hdl.handle.net/20.500.14352/44606
LA eng
NO Fernández Lucas, A. A., Zuluaga Arias, M. P., Abásolo, D. et al. «Brain Oscillatory Complexity across the Life Span». Clinical Neurophysiology, vol. 123, n.o 11, noviembre de 2012, pp. 2154-62. DOI.org (Crossref), https://doi.org/10.1016/j.clinph.2012.04.025.
NO Ministerio de Economía, Comercio y Empresa (España)
NO Fondo Europeo de Desarrollo Regional
DS Docta Complutense
RD 13 abr 2025