%0 Journal Article
%A Muñoz Sáez, Emma
%A Munck García, Estefanía de
%A Arahuetes Portero, Rosa María
%A Vicente, Francisca
%A Ortiz López, Francisco Javier
%A Cantizani, Juan
%A Gómez Miguel, Begoña
%T Neuroprotective role of sphingosine-1-phosphate in L-BMAA treated neuroblastoma cells (SH-SY5Y)
%D 2015
%@ 0304-3940
%U https://hdl.handle.net/20.500.14352/23381
%X Sphingosine-1-phosphate (S1P) is a bioactive lipid which regulates proliferation, cell migration, survival and differentiation by specific receptors activation. We studied its effects on L-BMAA treated neuroblastoma cells (SH-SY5Y), an amino acid that can trigger neurodegenerative diseases such as amyotrophic lateral sclerosis/Parkinson dementia complex (ALS/PDC). We found that S1P protects from necrosis and prevents the GSK3 increasing as long as the PI3K/AKT pathway is active. Moreover, GSK3 inhibition protects against neuronal death caused by L-BMAA.
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