RT Journal Article
T1 Neuroprotective role of sphingosine-1-phosphate in L-BMAA treated neuroblastoma cells (SH-SY5Y)
A1 Muñoz Sáez, Emma
A1 Munck García, Estefanía de
A1 Arahuetes Portero, Rosa María
A1 Vicente, Francisca
A1 Ortiz López, Francisco Javier
A1 Cantizani, Juan
A1 Gómez Miguel, Begoña
AB Sphingosine-1-phosphate (S1P) is a bioactive lipid which regulates proliferation, cell migration, survival and differentiation by specific receptors activation. We studied its effects on L-BMAA treated neuroblastoma cells (SH-SY5Y), an amino acid that can trigger neurodegenerative diseases such as amyotrophic lateral sclerosis/Parkinson dementia complex (ALS/PDC). We found that S1P protects from necrosis and prevents the GSK3 increasing as long as the PI3K/AKT pathway is active. Moreover, GSK3 inhibition protects against neuronal death caused by L-BMAA.
PB Elsevier
SN 0304-3940
YR 2015
FD 2015-04-23
LK https://hdl.handle.net/20.500.14352/23381
UL https://hdl.handle.net/20.500.14352/23381
LA eng
NO Ministerio de Economía y Competitividad (MINECO)
NO FUNDELA (Spanish ALS Foundation)
NO Medical Chemistry department of CSIC (Spanish National Research Council)
DS Docta Complutense
RD 16 may 2024