RT Journal Article
T1 MoS2 flakes stabilized with DNA/RNA nucleotides: In vitro cell response
A1 Cicuéndez Maroto, Mónica
A1 Silva, Virgília
A1 Santos, Joana
A1 Coimbra, Andreia
A1 Oliveira, Helena
A1 Ayán-Varela, Miguel
A1 Paredes, Juan Ignacio
A1 Villar-Rodil, Silvia
A1 Vila Gonzalo, María
AB Two-dimensional transition metal dichalcogenides (TMDCs), such as MoS2 and WS2, have recently emerged as nanomaterials with potential use in biomedicine. An attractive means to favor their interaction with biological media is the use of proper biomolecules as exfoliating/dispersing agents. Here, MoS2 flakes were stabilized with different small functional biomolecules such as adenosine monophosphate (AMP), guanosine monophosphate (GMP) and flavin mononucleotide (FMN) through the strong nucleotide-MoS2 interaction of Lewis acid-base type, rather than just on the weak dispersive and hydrophobic forces commonly associated with the use of many surfactants. The impact of the nucleotide-stabilized MoS2 flakes on the viability and cell proliferation, on the production of intracellular reactive oxygen species (ROS), and on the preosteoblast differentiation process (early stage) has been also evaluated, as well as the incorporation and intracellular localization of the nanomaterials by MC3T3-E1 and Saos-2 cells. The nucleotide-stabilized MoS2 flakes were found to exhibit excellent biocompatibility. Furthermore, their incorporation did not affect the integrity of the cell plasma membrane, which makes them ideal candidates for delivering drug/gene directly into cells. The in vitro cell response of tumor cells to these nanomaterials differs from that of undifferentiated cells, which provides the basis for their potential use in cancer therapy.
PB Elsevier
SN 0928-4931
YR 2019
FD 2019
LK https://hdl.handle.net/20.500.14352/96400
UL https://hdl.handle.net/20.500.14352/96400
LA eng
NO Cicuéndez M, Silva VS, Santos J, Coimbra A, Oliveira H, Ayán-Varela M, Paredes JI, Villar-Rodil S, Vila M. MoS2 flakes stabilized with DNA/RNA nucleotides: In vitro cell response. Mater Sci Eng C Mater Biol Appl. 2019 Jul;100:11-22. doi: 10.1016/j.msec.2019.02.002. Epub 2019 Feb 7. PMID: 30948045
NO Ministerio de Economía y Competitividad (España)
NO European Commission
NO Principado de Asturias
DS Docta Complutense
RD 20 mar 2026