RT Journal Article
T1 Identification of six cardiovascular risk biomarkers in the young population: A promising tool for early prevention
A1 Martínez Santos, Paula, Paula
A1 Baldán Martín, Montserrat
A1 López, Juan A.
A1 Martín Lorenzo, Marta
A1 Santiago Hernández, Aránzazu
A1 Agudiez, Marta
A1 Cabrera Sierra, Martha
A1 Calvo, Eva
A1 Vázquez, Jesús
A1 Ruiz Hurtado, Gema
A1 Vivanco, Fernando
A1 Ruilope, Luis M
A1 Barderas, María G.
A1 Álvarez Llamas, Gloria
AB Background and aimsThe predictive value of traditional CV risk calculators is limited. Novel indicators of CVD progression are needed particularly in the young population. The main aim of this study was the identification of a molecular profile with added value to classical CV risk estimation.MethodsEighty-one subjects (30–50 years) were classified in 3 groups according to their CV risk: healthy subjects; individuals with CV risk factors; and those who had suffered a previous CV event. The urine proteome was quantitatively analyzed and significantly altered proteins were identified between patients' groups, either related to CV risk or established organ damage. Target-MS and ELISA were used for confirmation in independent patients’ cohorts. Systems Biology Analysis (SBA) was carried out to identify functional categories behind CVD.Results4309 proteins were identified, 75 of them differentially expressed. ADX, ECP, FETUB, GDF15, GUAD and NOTCH1 compose a fingerprint positively correlating with lifetime risk estimate (LTR QRISK). Best performance ROC curve was obtained when ECP, GDF15 and GUAD were combined (AUC = 0.96). SBA revealed oxidative stress response, dilated cardiomyopathy, signaling by Wnt and proteasome, as main functional processes related to CV risk.ConclusionsA novel urinary protein signature is shown, which correlates with CV risk estimation in young individuals. Pending further confirmation, this six-protein-panel could help in CV risk assessment.
PB Elsevier
SN 1879-1484
YR 2019
FD 2019-03
LK https://hdl.handle.net/20.500.14352/13505
UL https://hdl.handle.net/20.500.14352/13505
LA eng
NO Instituto de Salud Carlos III (ISCIII)
NO Fondo Europeo de Desarrollo Regional (FEDER)
NO Fundación SENEFRO
NO Fundación Íñigo Álvarez de Toledo
NO Fundación Conchita Rábago de Jiménez Díaz
DS Docta Complutense
RD 11 abr 2025