RT Journal Article T1 The Topographical Effect of Optical Zone Diameter in Orthokeratology Contact Lenses in High Myopes A1 Carracedo Rodríguez, Juan Gonzalo A1 Espinosa Vidal, Teresa M. A1 Martínez Alberquilla, Irene A1 Batres Valderas, Laura AB Purpose. To evaluate the effect of the optical zone diameter (OZ) in orthokeratology contact lenses regarding the topographical profile in patients with high myopia (−4.00 D to −7.00 D) and to study its effect over the visual quality. Materials and Methods. Twelve patients (18 eyes) were fitted with overnight orthokeratology (OrthoK) with a randomized 6 mm or 5 mm OZ lens worn for 2 weeks, followed by a 2-week washout period, between both designs. Keratometry (K) readings, optical zone treatment diameter (OZT), peripheral ring width (PRW), higher-order aberrations (HOA), high (HC) and low contrast (LC) visual acuity, and subjective vision and comfort were measured at baseline and after 2 weeks of OrthoK lens wear of each contact lens. Results. No significant differences were found between any measurements for the same subject at both baselines ( value > 0.05). There was no difference between OZ lens designs found in refraction, subjective vision or comfort, and HC and LC visual acuity. Contrast sensitivity was decreased in the 5 mm OZ lens design compared with 6 mm OZ design (-value < 0.05). 5 mm OZ design provoked a greater flattening, more powerful midperipheral ring and 4th-order corneal and total spherical aberration than the 6 mm OZ design, being statistically significant after 7 days, for corneal aberration, and 15 days, for corneal and total, of wearing the lens (-value < 0.05). The OZT obtained were 2.8 ± 0.2 mm and 3.1 ± 0.1 mm for 5 mm and 6 mm OZ design, respectively (-value < 0.05). Regarding PRW, the 5 mm OZ design had a wider ring width in both the nasal and temporal zones (-value < 0.05). Conclusions. A smaller diameter optical zone (5 mm) in orthokeratology lenses produces a smaller treatment area and a larger and more powerful midperipheral ring, increasing the 4th-order spherical aberration that affects only the contrast sensitivity but without differences in visual acuity and subjective vision compared with a larger OZ diameter (6 mm). PB Hindawi SN 2090-004X YR 2019 FD 2019-01-02 LK https://hdl.handle.net/20.500.14352/13115 UL https://hdl.handle.net/20.500.14352/13115 LA eng NO Received 18 October 2018; Revised 29 November 2018; Accepted 16 December 2018; Published 2 January 2019 DS Docta Complutense RD 6 may 2024